685506-42-7

Basic information

• Product Name: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea
• Synonyms: GSK 264220A;N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea;1-(2-methyl-5-piperidin-1-ylsulfonylfuran-3-yl)-3-phenylurea
• CAS NO: 685506-42-7
• Molecular Formula: C₁₇H₂₁N₃O₄S
• Molecular Weight: 363.43134
• Mol File: 685506-42-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Store at +4°C
• CAS DataBase Reference: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea(685506-42-7)
• EPA Substance Registry System: N-[2-Methyl-5-(1-piperidinylsulfonyl)-3-furanyl]-N'-phenylurea(685506-42-7)

Safety Data

• Hazardous Substances Data: 685506-42-7(Hazardous Substances Data)

Usage

Uses

GSK 264220A is an endothelial lipase and lipoprotein lipase inhibitor, expected to be useful for the treatment of cardiovascular disease.

Upstream product

• 306936-38-9 C₁₁H₁₅NO₅S 
• 62-53-3 aniline 

Relevant articles and documents

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors

Endothelial lipase (EL) activity has been implicated in HDL catabolism, vascular inflammation, and atherogenesis, and inhibitors are therefore expected to be useful for the treatment of cardiovascular disease. Sulfonylfuran urea 1 was identified in a high-throughput screening campaign as a potent and non-selective EL inhibitor. A lead optimization effort was undertaken to improve potency and selectivity, and modifications leading to improved LPL selectivity were identified. Radiolabeling studies were undertaken to establish the mechanism of action for these inhibitors, which were ultimately demonstrated to be irreversible inhibitors.