685563-27-3

Basic information

• Product Name: 1H-Pyrrole-2-carboxylicacid,2-methoxyethylester(9CI)
• Synonyms: 1H-Pyrrole-2-carboxylicacid,2-methoxyethylester(9CI)
• CAS NO: 685563-27-3
• Molecular Formula: C₈H₁₁NO₃
• Molecular Weight: 169.17784
• Product Categories: GLYCINESCAFFOLD
• Mol File: 685563-27-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-2-carboxylicacid,2-methoxyethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylicacid,2-methoxyethylester(9CI)(685563-27-3)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylicacid,2-methoxyethylester(9CI)(685563-27-3)

Safety Data

• Hazardous Substances Data: 685563-27-3(Hazardous Substances Data)

Upstream product

• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 109-86-4 2-methoxy-ethanol 

Downstream Products

• 685563-17-1 1-(2-amino-5-chloro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid 2-methoxy-ethyl ester 
• 685563-15-9 1-(5-chloro-2-nitro-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid 2-methoxy-ethyl ester 

Relevant articles and documents

Anti-HIV-1 activity of pyrryl aryl sulfone (PAS) derivatives: Synthesis and SAR studies of novel esters and amides at the position 2 of the pyrrole nucleus

A SAR study has been performed in order to evaluate how much the ester function could be a determinant for the anti-human immunodeficiency virus type-1 activity of pyrryl aryl sulfones (PASs), a potent family of non-nucleoside reverse transcriptase (RT) inhibitors discovered in the last years. Twenty-three new esters were prepared with the aim to enhance the inhibitory potency of 4a and 4c, two PAS agents endowed with good activity (EC50 = 0.14 μM) and deprived of cytotoxicity up to >200 μM. None of test derivatives was as potent as 4a and 4c and lacked of selectivity due to their higher cytotoxicity (compounds 22-25). Antiviral activity correlate with an ester ramified chain.