68560-11-2

Usage

Chemical structure

Nitro compound with a dioxole ring and a methylthio group

Usage

Intermediate in the synthesis of various pharmaceuticals and agrochemicals

Environmental impact

Potential environmental contaminant

Toxicity

May have toxic effects on aquatic organisms

Handling and disposal

Important to handle and dispose of with care to prevent environmental harm

Upstream product

• 74-93-1 methylthiol 
• 7748-58-5 1-bromo-4,5-methylenedioxy-2-nitrobenzene 
• 5354-08-5 5-(methylthio)benzo[d][1,3]dioxole 

Downstream Products

• 68560-13-4 6-(methylthio)benzo[d][1,3]dioxol-5-amine 
• 1061318-30-6 5-iodo-6-(methylthio)benzo[d][1,3]dioxole 

Relevant academic research and scientific papers

FUSED AMINO PYRIDINE AS HSP90 INHIBITORS

The present invention relates to HSP90 inhibitors containing fused amino pyridine core that are useful as inhibitors of HSP90 and their use in the treatment of HSP90 related diseases and disorders such as cancer, an autoimmune disease, or a neurodegenerative disease.

Synthesis and blood pressure lowering activity of 3-(substituted-amino)-1,2,4-benzothiadazine 1-oxide derivatives

A series of (substituted amino)-1,2,4-benzothiadiazine 1-oxides has been synthesized and most members of the series have been shown to have blood-pressure lowering effects in normotensive rabbits and in spontaneously hypertensive rats. The most active member of the series was 3-[4-(2-furoyl)-1-piperazinyl]-6,7-dimethoxy-1-methyl-1H-1,2,4-benzothiadiazine 1-oxide hydrochloride. This compound in animal tests was equipotent to the known antihypertensive Prazosin.

1-Substituted-3-amino-6,7-dialkoxy-1H-1,2,4-benzothiadiazine-1-oxides

1-Substituted-3-amino-6,7-dialkoxy-1H-1,2,4-benzothiadiazine-1-oxides, useful as hypotensive agents.