685829-48-5

Basic information

• Product Name: N,N-Diethyl-3-(1-hydroxy-naphthalen-2-yl)-3-oxo-2-phenyl-propionamide
• Synonyms: N,N-Diethyl-3-(1-hydroxy-naphthalen-2-yl)-3-oxo-2-phenyl-propionamide
• CAS NO: 685829-48-5
• Molecular Weight: 361.441
• Mol File: 685829-48-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N,N-Diethyl-3-(1-hydroxy-naphthalen-2-yl)-3-oxo-2-phenyl-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Diethyl-3-(1-hydroxy-naphthalen-2-yl)-3-oxo-2-phenyl-propionamide(685829-48-5)
• EPA Substance Registry System: N,N-Diethyl-3-(1-hydroxy-naphthalen-2-yl)-3-oxo-2-phenyl-propionamide(685829-48-5)

Safety Data

• Hazardous Substances Data: 685829-48-5(Hazardous Substances Data)

Upstream product

• 103-80-0 phenylacetyl chloride 
• 85630-39-3 1-naphthyl N,N-diethylcarbamate 
• 211449-33-1 Diethyl-carbamic acid 2-phenylacetyl-naphthalen-1-yl ester 

Downstream Products

• 19484-59-4 4-hydroxy-3-phenyl-benzo[h]chromen-2-one 

Relevant articles and documents

Directed ortho metalation-cross coupling links. Carbamoyl rendition of the Baker-Venkataraman rearrangement. Regiospecific route to substituted 4- hydroxycoumarins

A new carbamoyl Baker-Venkataraman rearrangement (4) which allows a general synthesis of substituted 4-hydroxycoumarins 8 in 43-82% overall yields is described; the intermediate arylketones 6 are efficiently prepared (59-91% yields) via a Directed ortho Metalation - Negishi cross coupling protocol from arylcarbamates 5 and the overall sequence provides a regiospecific anionic Friedel-Crafts complement for the construction of ortho-acyl phenols and coumarins.