685835-75-0

Basic information

• Product Name: (1R)-2-O-methanesulfonyl-1-phenyl-1-O-vinyl-1,2-ethanediol
• CAS NO: 685835-75-0
• Molecular Weight: 242.296
• Mol File: 685835-75-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R)-2-O-methanesulfonyl-1-phenyl-1-O-vinyl-1,2-ethanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-2-O-methanesulfonyl-1-phenyl-1-O-vinyl-1,2-ethanediol(685835-75-0)
• EPA Substance Registry System: (1R)-2-O-methanesulfonyl-1-phenyl-1-O-vinyl-1,2-ethanediol(685835-75-0)

Safety Data

• Hazardous Substances Data: 685835-75-0(Hazardous Substances Data)

Upstream product

• 111-34-2 -butyl vinyl ether 
• 343239-88-3 (1R)-2-O-methanesulfonyl-1-phenyl-1,2-ethanediol 
• 16355-00-3 (R)-1-phenyl-1,2-ethanediol 

Relevant articles and documents

Synthesis, biological, and chiroptical activity of 3-phenyl-clavams

The [2+2]cycloaddition of chlorosulfonyl isocyanate to simple vinyl ethers derived from the 2-O-sulfonylated (R) and (S) 1-phenyl-1,2-ethanediol leads to 4-alkoxy-azetidin-2-ones with a moderate stereoselectivity. The cycloaddition to analogous (Z)-propenyl ethers proceeds stereospecifically with the retention of the olefin configuration. The intramolecular alkylation of β-lactam nitrogen atom furnished all possible stereoisomers of 3-phenyl- and 6-methyl-3-phenyl-clavams. The biological and chiroptical activity of synthesized clavams was investigated. The (3R,5R)-diastereomer 30 showed higher inhibition of bacterial enzymes than other related compounds.