685862-10-6 Usage
Molecular structure
1-quinazolin-4-yl-piperidine-4-carboxylic acid consists of a quinazoline ring fused to a piperidine ring and a carboxylic acid functional group.
Classification
Heterocyclic compound.
Usage
Building block in the synthesis of various pharmaceutical compounds.
Biological activity
Potential as an antitumor agent and in the development of novel therapeutic drugs for various medical conditions.
Importance
Unique structural features make it an important intermediate in the synthesis of biologically active compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 685862-10-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,5,8,6 and 2 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 685862-10:
(8*6)+(7*8)+(6*5)+(5*8)+(4*6)+(3*2)+(2*1)+(1*0)=206
206 % 10 = 6
So 685862-10-6 is a valid CAS Registry Number.
685862-10-6Relevant articles and documents
Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease
Lu, Tianbao,Connolly, Peter J.,Philippar, Ulrike,Sun, Weimei,Cummings, Maxwell D.,Barbay, Kent,Gys, Luc,Van Nuffel, Luc,Austin, Nigel,Bekkers, Mariette,Shen, Fang,Cai, Ann,Attar, Ricardo,Meerpoel, Lieven,Edwards, James
, (2019/11/11)
We describe a series of potent and highly selective small-molecule MALT1 inhibitors, optimized from a High-Throughput Screening hit. Advanced analogues such as compound 40 show high potency (IC50: 0.01 μM) in a biochemical assay measuring MALT1 enzymatic activity, as well as in cellular assays: Jurkat T cell activation (0.05 μM) and IL6/10 secretion (IC50: 0.10/0.06 μM) in the TMD8 B-cell lymphoma line. Compound 40 also inhibited cleavage of the MALT1 substrate RelB (IC50: 0.10 μM). Mechanistic enzymology results suggest that these compounds bind to the known allosteric site of the protease.
