685876-05-5Relevant academic research and scientific papers
Improved stability of proline-derived direct thrombin inhibitors through hydroxyl to heterocycle replacement
Chobanian, Harry R.,Pio, Barbara,Guo, Yan,Shen, Hong,Huffman, Mark A.,Madeira, Maria,Salituro, Gino,Terebetski, Jenna L.,Ormes, James,Jochnowitz, Nina,Hoos, Lizbeth,Zhou, Yuchen,Lewis, Dale,Hawes, Brian,Mitnaul, Lyndon,O'Neill, Kim,Ellsworth, Kenneth,Wang, Liangsu,Biftu, Tesfaye,Duffy, Joseph L.
, p. 553 - 557 (2015/05/27)
Modification of the previously disclosed (S)-N-(2-(aminomethyl)-5-chlorobenzyl)-1-((R)-2-hydroxy-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamide 2 by optimization of the P3 group afforded novel, low molecular weight thrombin inhibitors. Heterocycle replace
