685881-29-2

Upstream product

• 685881-15-6 4-(6-allyl-benzo[1,3]dioxol-5-yl)-4-(3,4,5-trimethoxy-phenyl)-but-2-ynoic acid ethyl ester 
• 685881-28-1 4-(6-allyl-benzo[1,3]dioxol-5-yl)-3-iodo-4-(3,4,5-trimethoxy-phenyl)-but-2-enoic acid ethyl ester 

Downstream Products

• 59123-24-9 (±)-β-apopicropodophyllin 

Relevant academic research and scientific papers

Rhenium-catalyzed aromatic propargylation

A mild aromatic propargylation reaction, employing an air- and moisture-tolerant rhenium-oxo complex ((dppm)ReOCl3) as a catalyst and a propargyl alcohol as the electrophile, is described. The reaction tolerates a broad range of functional groups and regioselectively affords propargylic arenas without formation of the isomeric allenyl adducts. The potential of this rhenium(V)-catalyzed reaction is exemplified by application of the propargylation to the synthesis of O-methyldetrol, mimosifoliol, and β-apopicropodophyllin.