685886-66-2Relevant academic research and scientific papers
Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: Potent and orally active antagonists of corticotropin-releasing factor 1 receptor
Takahashi, Yoshinori,Hibi, Shigeki,Hoshino, Yorihisa,Kikuchi, Koichi,Shin, Kogyoku,Murata-Tai, Kaoru,Fujisawa, Masae,Ino, Mitsuhiro,Shibata, Hisashi,Yonaga, Masahiro
experimental part, p. 5255 - 5269 (2012/08/27)
Design, synthesis, and structure-activity relationships of a series of 3-dialkylamino-7-phenyl pyrazolo[1,5-a]pyridines (I) as selective antagonists of the corticotropin-releasing factor 1 (CRF1) receptor are described. The most prominent compound to emerge from this work, 46 (E2508), exhibits potent in vitro activity, excellent drug-like properties, and robust oral efficacy in animal models of stress-related disorders. It has advanced into clinical trials.
7-phenylpyrazolopyridine compounds
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Page 32-33, (2008/06/13)
A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.
