685896-46-2

Upstream product

• 685896-45-1 (3-{[(2R)-2-formyl-5-oxopyrrolidin-1-yl]-methyl}-phenyl)-acetonitrile 
• 82101-87-9 oxo-2-phenyl-3 propylphosphonate diethylique 

Downstream Products

• 685896-47-3 [3-({(2R)-2-[(1E)-3-hydroxy-4-phenylbut-1-enyl]-5-oxopyrrolidin-1-yl}-methyl)-phenyl]-acetonitrile 

Relevant academic research and scientific papers

PYRROLIDIN-2-ON DERIVATIVES AS EP4 RECEPTOR AGONISTS

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors having structural formula (I), their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.