685896-64-4Relevant academic research and scientific papers
Synthesis of enantiopure 7-azanorbornane proline-α-amino acid chimeras by highly efficient HPLC resolution of a phenylalanine analogue
Gil, Ana M.,Bunuel, Elena,Lopez, Pilar,Cativiela, Carlos
, p. 811 - 819 (2007/10/03)
The enantiomerically pure conformationally constrained prolines, (1S,2S,4R)- and (1R,2R,4S)-2-phenyl-7-azabicyclo [2.2.1]heptane-1-carboxylic acid hydrochlorides, which are proline-phenylalanine chimeras, have been separately obtained by resolution of a key intermediate using chiral high performance liquid chromatography. The efficiency of the chromatographic resolution provides a general methodology for the preparation of both enantiomers of a broad variety of proline-α-amino acid chimeras with a 7-azanorbornane skeleton in enantiomerically pure form.
