68601-76-3

Upstream product

• 68601-75-2 methyl 2,4-di-O-benzyl-(2-O-acetyl-3,4,6-tri-O-benzyl-D-mannopyranosyl-α-(1→2)-3,4,6-tri-O-benzyl-D-mannopyranosyl-α-(1→3))-(2-O-acetyl-3,4,6-tri-O-benzyl-D-mannopyranosyl-α-(1→2)-3,4,6-tri-O-benzyl-D-mannopyranosyl-α-(1→6))-α-D-mannopyranoside 
• 68601-73-0 methyl (3,4,6-tri-O-benzyl-α-D-mannopyranosyl-(1->3))-(3,4,6-tri-O-benzyl-α-D-mannopyranosyl-(1->6))-2,4-di-O-benzyl-α-D-mannopyranoside 

Relevant academic research and scientific papers

Rapid assembly of gp120 oligosaccharide moieties via one-pot glycosidation-deprotection sequences

Mannosyl trihaloacetimidate donors equipped with a 2-O-Fmoc group can be effectively activated by catalytic Bi(OTf)3 in glycosidations. Despite the expected participating effect of the Fmoc group, the reaction solvent was found to be decisive f

One-pot catalytic glycosidation/Fmoc removal - An iterable sequence for straightforward assembly of oligosaccharides related to HIV gp120

The removal of a transient Fmoc protecting group can be simply performed by the addition of excess Et3N just after the accomplishment of a Bi(OTf)3-promoted glycosidation reaction. The obtained oligosaccharide can be directly employed as a glycosyl acceptor for further elongation of the saccharide. The preparation of biologically important, linear and branched mannans incorporated into HIV gp 120 demonstrates that the iteration of this one-pot sequence leads to a very straightforward oligosaccharide assembly.

SYNTHETIC STUDIES ON CELL SURFACE GLYCANS 3 BRANCHING PENTASACCHARIDES OF GLYCOPROTEIN

Synthetic routes for the branching pentasaccharides 4 and 5 of glycoproteins are described in a regio- and stereo-controlled way.