686268-38-2

Upstream product

• 686268-37-1 ethyl (5-methoxy-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)acetate 
• 97484-73-6 N-benzyl-2H-pyrido<2,3-d><1.3>oxazine-2,4 1H-dione 
• 145255-82-9 N-butyl-3-azaisatoic anhydride 
• 155983-99-6 5-methoxy-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide 
• 393089-55-9 2-amino-3-methoxybenzenesulphonamide 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 686268-40-6 1-benzyl-4-hydroxy-3-(5-hydroxy-1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-1,8-naphthyridin-2(1H)-one 

Relevant academic research and scientific papers

Inhibitors of HCV NS5B polymerase: Synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring

A series of non-nucleoside HCV NS5B polymerase inhibitors based on the N-1-benzyl or N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine core substituted in the D-ring aromatic moiety have been prepared and evaluated. Aromatic substituents extending from position 7 of the D-ring exhibited excellent potency against both genotypes 1a and 1b.

Anti-infective agents

Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.