68627-06-5

Basic information

• Product Name: C₁₈H₂₀N₂O₄
• Synonyms: C₁₈H₂₀N₂O₄
• CAS NO: 68627-06-5
• Molecular Weight: 328.368
• Mol File: 68627-06-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₀N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₀N₂O₄(68627-06-5)
• EPA Substance Registry System: C₁₈H₂₀N₂O₄(68627-06-5)

Safety Data

• Hazardous Substances Data: 68627-06-5(Hazardous Substances Data)

Upstream product

• 68621-88-5 (3-aminophenyl)carbamic acid tert-butyl ester 
• 1885-14-9 phenyl chloroformate 

Relevant articles and documents

Heat shock protein 90 (Hsp90)/Histone deacetylase (HDAC) dual inhibitors for the treatment of azoles-resistant Candida albicans

Clinical treatment of candidiasis has suffered from increasingly severe drug resistance and limited efficacy. Thus, novel strategies to deal with drug resistance are highly desired to develop effective therapeutic agents. Herein, dual inhibition of heat shock protein 90 (Hsp90) and histone deacetylase (HDAC) was validated as a new strategy to potentiate efficacy of fluconazole against resistant Candida albicans infections. The first generation of Hsp90/HDAC dual inhibitors were designed as synergistic enhancers to treat azoles-resistant candidiasis. In particular, compound J5 exhibited fungal-selective inhibitory effects on Hsp90 and HDACs, leading to low toxicity and excellent in vitro (FICI = 0.266) and in vivo synergistic antifungal potency to treat fluconazole resistant candidiasis. Antifungal-mechanistic investigation revealed that compound J5 suppressed important virulence factors and down-regulated expression of resistance-associated genes. Therefore, Hsp90/HDAC dual inhibitors represent a new strategy for the development of novel antifungal therapeutics to combat azole-resistant candidiasis.