686274-47-5

Upstream product

• 108-24-7 acetic anhydride 
• 686274-46-4 (R)-N-[3-hydroxy-2,2-dimethyl-(3-phenyl-furan-2-yl)-propyl]-4-methyl-benzenesulfonamide 
• 686274-62-4 (R)-(4R,5R)-3-{3-[4,5-bis(methoxy-diphenyl-methyl)-1,3,2-dioxaborolan-2-yl]-furan-2-yl}-2,2-dimethyl-3-(toluene-4-sulfonylamino)propionic acid ethyl ester 
• 686274-39-5 (4R,5R)-N-{3-[4,5-bis(methoxydiphenylmethyl)-1,3,2-dioxaborolan-2-yl]-furan-2-ylmethylene}-4-methyl-benzenesulfonamide 
• 686274-45-3 (R)-(4R,5R)-N-(1-{3-[4,5-bis(methoxy-diphenyl-methyl)-1,3,2-dioxaborolan-2-yl]-furan-2-yl}-3-hydroxy-2,2-dimethyl-propyl)-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Diastereoselective Addition Reactions of Furyl Sulfonylimine Using Chiral Boronates as Auxiliary: Application to the Enantioselective Synthesis of 2,3-Disubstituted Furyl Sulfonylamides

The addition reactions of various nucleophiles to a furyl sulfonylimine bearing a chiral boronate at the C-3 position furnished chromatographically separable diastereomers. The R diastereoselection was found to be more favorable. Further transformation of C-B bonds to C-C bonds was achieved by using standard Suzuki coupling conditions to give optically active 2,3-disubstituted furyl sulfonylamides.