68630-75-1

Basic information

• Product Name: BUSERELIN
• Synonyms: 6-(o-(1,1-dimethylethyl)-d-serine)-luteinizinghormone-releasingfactor(pig;9-(n-ethyl-l-prolinamide)-10-deglycinamide,monoacetate(salt);buserelinacetate;hoe766;hoe766mp;(DES-GLY10,D-SER(TBU)6,PRO-NHET9)-LHRH;PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET;P-GLU-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET
• CAS NO: 68630-75-1
• Molecular Formula: C60H86N16O13
• Molecular Weight: 1239.42
• EINECS: 261-061-9
• Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
• Mol File: 68630-75-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 186-188°C
• Boiling Point: 1691.5°C at 760 mmHg
• Flash Point: 976.8°C
• Appearance: /
• Density: 1.43 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Storage Temp.: −20°C
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: BUSERELIN(CAS DataBase Reference)
• NIST Chemistry Reference: BUSERELIN(68630-75-1)
• EPA Substance Registry System: BUSERELIN(68630-75-1)

Safety Data

• Hazard Codes: T
• Statements: 60
• Safety Statements: 53-22-36/37/39-45
• WGK Germany: 3
• RTECS: OK6370000
• Hazardous Substances Data: 68630-75-1(Hazardous Substances Data)

Usage

Description

Buserelin acetate is a potent analog of the hypothalamic hormone, luteinizing hormone-releasing hormone (LH-RH). Chronic administration of higher doses of buserelin desensitizes the pituitary, resulting in a decreased production of luteinizing hormone (LH), follicle stimulating hormone (FSH), and eventually sex steroids (testosterone in males and estradiol in females). Initial approval is for use in achieving medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of endometriosis, leiomyoma, precocious puberty, advanced breast cancer and infertility.

Chemical Properties

White Solid

Originator

Hoechst AG (W. Germany)

Uses

Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal).

Biochem/physiol Actions

Buserelin is an LH-RH agonist.

InChI:InChI=1/C60H86N16O13.C2H4O2/c1-7-64-57(87)48-15-11-23-76(48)58(88)41(14-10-22-65-59(61)62)69-51(81)42(24-33(2)3)70-56(86)47(31-89-60(4,5)6)75-52(82)43(25-34-16-18-37(78)19-17-34)71-55(85)46(30-77)74-53(83)44(26-35-28-66-39-13-9-8-12-38(35)39)72-54(84)45(27-36-29-63-32-67-36)73-50(80)40-20-21-49(79)68-40;1-2(3)4/h8-9,12-13,16-19,28-29,32-33,40-48,66,77-78H,7,10-11,14-15,20-27,30-31H2,1-6H3,(H,63,67)(H,64,87)(H,68,79)(H,69,81)(H,70,86)(H,71,85)(H,72,84)(H,73,80)(H,74,83)(H,75,82)(H4,61,62,65);1H3,(H,3,4)/t40-,41-,42-,43-,44-,45-,46-,47+,48-;/m0./s1