68634-20-8Relevant academic research and scientific papers
Synthesis and antiproliferative activity of minor hops prenylflavonoids and new insights on prenyl group cyclization
Pop?o′ nski, Jaros?aw,Turlej, Eliza,Sordon, Sandra,Tronina, Tomasz,Bartma′ nska, Agnieszka,Wietrzyk, Joanna,Huszcza, Ewa
, (2018/04/06)
Synthesis of minor prenylflavonoids found in hops and their non-natural derivatives were performed. The antiproliferative activity of the obtained compounds against some human cancer cell lines was investigated. Using xanthohumol isolated from spent hops
An efficient synthesis of the phytoestrogen 8-prenylnaringenin from xanthohumol by a novel demethylation process
Wilhelm, Heike,Wessjohann, Ludger A.
, p. 6961 - 6966 (2007/10/03)
8-Prenylnaringenin, a flavonoid, is the strongest known phytoestrogen (plant derived estrogen mimic) used in phytomedicinal applications. Starting from xanthohumol a byproduct of hops-extraction, 8-prenylnaringenin can be synthesized via isoxanthohumol. Of various demethylation procedures tested, the best yield (92%) is obtained by treatment with scandium trifluoromethanesulfonate and potassium iodide without any need of protection. The demethylation with AlBr3/collidine and of the TIPS protected isoxanthohumol provides good results too.
Demethylxanthohumol: Isolation from Hops and Cyclisation to Flavanons
Haensel, Rudolf,Schulz, Jutta
, p. 37 - 40 (2007/10/02)
Demethylxanthohumol (1) was isolated together with xanthohumol (2) from freshly harvested strobili of hops (humulus lupulus L.).Structure proof of 1 is based on spectroscopic data and on the transformation of 1 and 2 into trimethylxanthohumol (3).Treatmen
