686351-06-4Relevant academic research and scientific papers
HIGH REFRACTIVE INDEX LIQUIDS BASED ON META-SUBSTITUTED S-ALKYL THIOETHERS
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Page/Page column 29; 30, (2018/03/09)
The present invention relates to liquid aromatic thioethers, a process for the preparation of the liquid aromatic thioethers, an article comprising the liquid aromatic thioethers as well as the use of the liquid aromatic thioethers as a component or substantial part of an optical liquid, window material, color filter, coating, varnish, lacquer, dye or pigment formulation, immersion liquid, calibration liquid or matching liquid, ingredient or additive in a plastic material or ingredient or additive in a polymer.
Synthesis of Thioethers and Thioesters with Alkyl Arylsulfinates as the Sulfenylation Agent under Metal-Free Conditions
Li, Yahui,Zhu, Fengxiang,Wang, Zechao,Wu, Xiao-Feng
supporting information, p. 3503 - 3507 (2016/12/26)
A study on the coupling of cycloalkanes with alkyl arylsulfinates has been performed. Using iodine as the catalyst, through C (Formula presented.) ?H bond activation and sulfinates reduction, a wide range of thioethers were produced in moderate to high yields. Additionally, various thiocarboxylic esters can also be produced by simply performing the reaction under CO pressure. Notably, this is the first report in which alkyl arylsulfinates were used as sulfenylation agents in a cross-coupling transformation.
Discovery of a rapidly metabolized, long-acting β2 adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing
Procopiou, Panayiotis A.,Barrett, Victoria J.,Biggadike, Keith,Butchers, Peter R.,Craven, Andrew,Ford, Alison J.,Guntrip, Stephen B.,Holmes, Duncan S.,Hughes, Sara C.,Jones, Anne E.,Looker, Brian E.,Mutch, Peter J.,Ruston, Mark,Needham, Deborah,Smith, Claire E.
supporting information, p. 159 - 170 (2014/02/14)
A series of novel, potent, and selective human β2 adrenoceptor agonists incorporating a sulfone moiety on the terminal right-hand-side phenyl ring of (R)-salmeterol is presented. Sulfone 10b had salmeterol-like potency and selectivity profile, long duration of action on guinea pig trachea, and longer than salmeterol duration of action in vivo, suitable for once-daily dosing. It had lower than salmeterol oral absorption in rat, lower bioavailability in rat and dog, and a high turnover in human hepatocytes. It was metabolized in human hepatocytes by hydroxylation, oxidation, cleavage, and conjugation; most of the metabolites would be expected to have reduced or no β2 activity. The 4-biphenylsulfonic acid was identified as a crystalline, non-hygroscopic salt of 10b, suitable for inhaled delivery. Furthermore, it was free of any genetic toxicity issues and was considered as a backup to vilanterol.
PHENETHANOLAMINE DERIVATIVE FOR THE TREATMENT OF RESPIRATORY DISEASES
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Page 51-52, (2010/02/06)
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases.
