68640-95-9

Basic information

• Product Name: 1-acetyl-2-chloro-1H-indole-3-carbaldehyde
• CAS NO: 68640-95-9
• Molecular Formula: C₁₁H₈ClNO₂
• Molecular Weight: 221.6397
• Mol File: 68640-95-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 362.2°C at 760 mmHg
• Flash Point: 172.9°C
• Density: 1.33g/cm³
• Vapor Pressure: 1.96E-05mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 1-acetyl-2-chloro-1H-indole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetyl-2-chloro-1H-indole-3-carbaldehyde(68640-95-9)
• EPA Substance Registry System: 1-acetyl-2-chloro-1H-indole-3-carbaldehyde(68640-95-9)

Safety Data

• Hazardous Substances Data: 68640-95-9(Hazardous Substances Data)

Usage

Appearance

Yellow to brown powder

Usage

Intermediate in the synthesis of pharmaceuticals and organic compounds

Application

Production of dyes and pigments

Functional groups

Aldehyde group and chloro group

Role

Valuable building block for creating chemical derivatives

Pharmacological activities

Studied for potential use as an antifungal and antibacterial agent

Industry

Widely utilized in the chemical and pharmaceutical industries

Upstream product

• 108-24-7 acetic anhydride 
• 5059-30-3 2-chloroindole-3-carboxaldehyde 

Relevant articles and documents

Synthesis of 2-amino-4H-thiazolo[5,4-b]indole and characterization of its colored conversion products with protein tyrosine phosphatase inhibitory activity

In DMSO-solution 2-amino-4H-thiazolo[5,4-b]indole is converted into a complex mixture of colored products. The three major conversion end-products, of which two are inhibitors of protein tyrosine phosphatases (PTPs), were isolated by chromatographic methods and their structures characterized by spectroscopic analysis, including NMR and MS combined with computer assisted structure elucidation, and, finally, confirmed by independent chemical synthesis. Synthesis of 2-amino-4H-thiazolo[5,4-b]indole as well as its N-acetyl derivatives prepared from either oxindole or 2-bromo-1-(2-nitro-phenyl)ethanone is described.