68646-49-1Relevant academic research and scientific papers
2:1 versus 1:1 Coupling of Alkylacetylenes with Secondary Amines: Selectivity Switching in 8-Quinolinolato Rhodium Catalysis
Morimoto, Yoshihiko,Hamada, Moe,Takano, Shotaro,Mochizuki, Katsufumi,Kochi, Takuya,Kakiuchi, Fumitoshi
supporting information, p. 3803 - 3808 (2021/04/05)
Both 2:1 and 1:1 couplings of alkylacetylenes with secondary amines were achieved using 8-quinolinolato rhodium catalysts and CsF. The 2:1/1:1 selectivity was switched by choosing the reaction solvent. In DMA, an unprecedented 2:1 coupling reaction of alkylacetylenes with amines proceeded to give 2-aminodiene products. One-pot 2:1 coupling/reduction provided rapid access to various allylamines, while one-pot coupling/hydrolysis gave enones as products. In toluene, anti-Markovnikov hydroamination occurred under relatively mild conditions to give 1:1 coupling products.
Desulfonylative Methenylation of β-Keto Sulfones
Pandey, Ganesh,Vaitla, Janakiram
supporting information, p. 4890 - 4893 (2015/10/12)
A one-step strategy for the synthesis of α-methenyl ketones from β-keto sufones is reported. Success of the methodology is elaborated for the synthesis of chromanones and isoflavanones in one-step.
An Efficient and Convenient Method for the Preparation of α-Methylenated Ketones from Silyl Enol Ethers
Hayashi, Masaji,Mukaiyama, Teruaki
, p. 1283 - 1286 (2007/10/02)
In the presence of a catalytic amount of stannous halide, silyl enol ethers react with bromomethyl methyl ether to give the corresponding α-bromoethyl ketones, which are smoothly converted to α-methylenated ketones on the successive addition of tertiary amine by one-pot procedure.This method is successfully applied to a synthesis of sarkomycin intermediate.
