68655-07-2Relevant academic research and scientific papers
5,6-Benzo analogues or prostaglandin E
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, (2008/06/13)
Disclosed are prostaglandin analogues having the structural formula, STR1 in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of --CH2 --CH-- or trans --CH=C--; T1 and T2 are attached to adjacent carbon atoms; T1 is selected from the group consisting of hydrogen or phenyl, provided T1 is phenyl only if T2 is lower alkyl; T2 is selected from the group consisting of n-pentyl or lower alkyl, provided T2 is lower alkyl only if T1 is phenyl; Or T1 and T2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.
5,6-Benzo analogues of prostaglandin E
-
, (2008/06/13)
Disclosed are prostaglandin analogues having the structural formula, STR1 in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of --CH2 --CH-- or trans --CH=C--; T1 and T2 are attached to adjacent carbon atoms; T1 is selected from the group consisting of hydrogen or phenyl, provided T1 is phenyl only if T2 is lower alkyl; T2 is selected from the group consisting of n-pentyl or lower alkyl, provided T2 is lower alkyl only if T1 is phenyl; Or T1 and T2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.
