68655-93-6Relevant academic research and scientific papers
A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorphenyl)propanamide and related compounds
Szmuszkovicz,Von Voigtlander,Kane
, p. 1230 - 1236 (2007/10/02)
A series of new nontricyclic antidepressant compounds was synthesized. A representative of this class is shown. Five structural parameters were investigated: ring size, cis/trans stereochemistry, amide substitution, aromatic substitution, and amine substi
N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression
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, (2008/06/13)
N-(2-aminocycloheptyl)N-alkanoylanilides and their 2-N-oxides of the formula STR1 e.g., trans-3,4-dichloro-N-[2-(dimethylamino)cycloheptyl]propionanilide, and their pharmacologically acceptable salts, have been found to possess potent Central Nervous System antidepressant properties. Many of them are new. These compounds are promising antidepressant drugs which are characterized by lower toxicity than imipramine, and long acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are disclosed.
