6866-70-2

Usage

Uses

Used in Organometallic Chemistry:
Phosphine oxide, tris(1,1-dimethylethyl)is used as a supporting ligand for transition metal catalysts in various organic reactions. Its strong ligand properties contribute to the efficiency and selectivity of these reactions.
Used in Organic Synthesis:
Phosphine oxide, tris(1,1-dimethylethyl)is utilized as a reagent in the synthesis of organic compounds, where it aids in the formation of desired products through its stabilizing and activating effects on metal complexes.
Used in Catalysis:
Phosphine oxide, tris(1,1-dimethylethyl)is employed in catalysis to enhance the performance of catalysts, particularly in transition metal-catalyzed reactions, due to its ability to stabilize metal complexes.
Used as a Reducing Agent:
In certain chemical reactions, Phosphine oxide, tris(1,1-dimethylethyl)- can act as a strong reducing agent, facilitating specific transformations that require reduction processes.

Upstream product

• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 98-80-6 phenylboronic acid 
• 13716-12-6 tri-tert-butyl phosphine 

Downstream Products

• 104092-16-2 ((t)Bu₃SiO)2HTa(OSi(t)Bu₂CMe₂CH₂) 
• 353300-68-2 ((C₄H₉)3SiO)3VOP(C₄H₉)3 
• 257870-27-2 Ta(OSi(C(CH₃)3)3)3(NC₅H₄CH₃) 
• 699010-60-1 [(C₅Me₅)Sc(tri-tert-butylphosphine oxide)Cl₂] 
• 1365042-89-2 Dy(NO₃)3(tri-tert-butylphosphine oxide)2 
• 1365043-03-3 Lu(NO₃)3(tri-tert-butylphosphine oxide)2 
• 1365042-95-0 Er(NO₃)3(tri-tert-butylphosphine oxide)2 
• 1335045-43-6 Br^(1-)*C₁₇H₄₂NOP₂Si⁽¹⁺⁾ 

Relevant academic research and scientific papers

Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis

The metal-free catalytic hydrogenation of secondary carboxylic acid amides is developed. The reduction is realized by two new catalytic reactions. First, the amide is converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides are hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mechanical calculations support an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.

Suzuki cross-couplings on aryl (heteroaryl) bromides and chlorides with bulky aliphatic phosphines/Pd(0)-triolefinic macrocyclic catalyst

The combination of a bulky aliphatic phosphine, e.g. tricyclohexylphosphine or the tetrafluoroborate salt of tri-tert-butylphosphine, with the Pd(0) complex of a 15-membered triolefinic macrocycle is an excellent catalyst for the Suzuki cross-coupling of aryl and heteroaryl bromides and chlorides. The palladium can be recovered in the form of the initial complex. Georg Thieme Verlag Stuttgart.

Sulfonamides having antiangiogenic and anticancer activity

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Peroxo-containing metal complexes having amine oxide, phosphine oxide, arsine oxide, pyridine N-oxide or pyridine ligands as epoxidation catalysts

PCT No. PCT/EP96/03888 Sec. 371 Date Mar. 11, 1998 Sec. 102(e) Date Mar. 11, 1998 PCT Filed Sep. 4, 1996 PCT Pub. No. WO97/10054 PCT Pub. Date Mar. 20, 1997Olefins can be epoxidized using catalysts I where M is a metal of the 4th to 7th transition group of the Periodic Table of the Elements, L1 is an amine oxide, phosphine oxide, arsine oxide, pyridine N-oxide or pyridine ligand of the formula II, III, VII or VIII, L2 is a customary auxiliary ligand or a further ligand L1 or a free coordination site, X is oxo oxygen or an imido ligand, m is 1 or 2, and n is 1, 2 or 3.

Preparation of epoxides from olefins using bis(triorganosilyl) peroxides in the presence of activators based on metallic acid derivatives

PCT No. PCT/EP97/00982 Sec. 371 Date Sep. 2, 1998 Sec. 102(e) Date Sep. 2, 1998 PCT Filed Feb. 28, 1997 PCT Pub. No. WO97/32867 PCT Pub. Date Sep. 12, 1997Epoxides are prepared from olefins using bis(triorganosilyl) peroxides in the presence of activators based on metalic acid derivatives of the formula where M is a metal of transition groups IV to VII, in particular molybdenum, tungsten or rhenium L is an uncharged ligand selected from the group consisting of amine oxides, phosphine oxides, arsine oxides, phosphoric triamides, formamides and pyridine N-oxides X is an inorganic ligand x is from 1 to 5 y is 0, 1 or 2, Z is 1 or 2 and n is 1 or 2.