6866-70-2

Basic information

• Product Name: Phosphine oxide, tris(1,1-dimethylethyl)-
• CAS NO: 6866-70-2
• Molecular Formula: C12H27OP
• Molecular Weight: 218.32
• Mol File: 6866-70-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Phosphine oxide, tris(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphine oxide, tris(1,1-dimethylethyl)-(6866-70-2)
• EPA Substance Registry System: Phosphine oxide, tris(1,1-dimethylethyl)-(6866-70-2)

Safety Data

• Hazardous Substances Data: 6866-70-2(Hazardous Substances Data)

Usage

Description

Phosphine oxide, tris(1,1-dimethylethyl)-, also known as tris(tert-butyl)phosphine oxide, is a white crystalline solid that serves as a strong ligand in organometallic chemistry. It is widely recognized for its ability to stabilize and activate metal complexes, as well as its function as a reagent in the synthesis of organic compounds.

Uses

Used in Organometallic Chemistry:
Phosphine oxide, tris(1,1-dimethylethyl)is used as a supporting ligand for transition metal catalysts in various organic reactions. Its strong ligand properties contribute to the efficiency and selectivity of these reactions.
Used in Organic Synthesis:
Phosphine oxide, tris(1,1-dimethylethyl)is utilized as a reagent in the synthesis of organic compounds, where it aids in the formation of desired products through its stabilizing and activating effects on metal complexes.
Used in Catalysis:
Phosphine oxide, tris(1,1-dimethylethyl)is employed in catalysis to enhance the performance of catalysts, particularly in transition metal-catalyzed reactions, due to its ability to stabilize metal complexes.
Used as a Reducing Agent:
In certain chemical reactions, this compound can act as a strong reducing agent, facilitating specific transformations that require reduction processes.

Upstream product

• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 98-80-6 phenylboronic acid 
• 13716-12-6 tri-tert-butyl phosphine 

Downstream Products

• 104092-16-2 ((t)Bu₃SiO)2HTa(OSi(t)Bu₂CMe₂CH₂) 
• 353300-68-2 ((C₄H₉)3SiO)3VOP(C₄H₉)3 
• 1335045-44-7 Br^(1-)*C₁₉H₄₀F₆NO₃P₂Si⁽¹⁺⁾ 
• 1335045-23-2 CF₃O₃S^(1-)*C₁₉H₄₀F₆NO₃P₂Si⁽¹⁺⁾ 
• 1335045-21-0 CF₃O₃S^(1-)*C₁₇H₄₂NOP₂Si⁽¹⁺⁾ 
• 1335045-43-6 Br^(1-)*C₁₇H₄₂NOP₂Si⁽¹⁺⁾ 
• 1365042-89-2 Dy(NO₃)3(tri-tert-butylphosphine oxide)2 
• 1365043-03-3 Lu(NO₃)3(tri-tert-butylphosphine oxide)2 
• 1365042-95-0 Er(NO₃)3(tri-tert-butylphosphine oxide)2 
• 699010-60-1 [(C₅Me₅)Sc(tri-tert-butylphosphine oxide)Cl₂] 

Relevant articles and documents

Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis

The metal-free catalytic hydrogenation of secondary carboxylic acid amides is developed. The reduction is realized by two new catalytic reactions. First, the amide is converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides are hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mechanical calculations support an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.

Sulfonamides having antiangiogenic and anticancer activity

Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Preparation of epoxides from olefins using bis(triorganosilyl) peroxides in the presence of activators based on metallic acid derivatives

PCT No. PCT/EP97/00982 Sec. 371 Date Sep. 2, 1998 Sec. 102(e) Date Sep. 2, 1998 PCT Filed Feb. 28, 1997 PCT Pub. No. WO97/32867 PCT Pub. Date Sep. 12, 1997Epoxides are prepared from olefins using bis(triorganosilyl) peroxides in the presence of activators based on metalic acid derivatives of the formula where M is a metal of transition groups IV to VII, in particular molybdenum, tungsten or rhenium L is an uncharged ligand selected from the group consisting of amine oxides, phosphine oxides, arsine oxides, phosphoric triamides, formamides and pyridine N-oxides X is an inorganic ligand x is from 1 to 5 y is 0, 1 or 2, Z is 1 or 2 and n is 1 or 2.