68671-47-6

Usage

Uses

Used in Biochemical Research:
p-nitrophenyl-D-lactic acid is used as a substrate in enzymatic reactions for [the purpose of studying enzyme kinetics and mechanisms].
Used in Pharmacological Research:
p-nitrophenyl-D-lactic acid is used as a model compound for [evaluating the effectiveness of drugs targeting specific enzymes].
Used in Drug Development:
p-nitrophenyl-D-lactic acid is used as a chemical intermediate for [the synthesis of new drugs that modulate enzyme activity].
Used in Clinical Diagnostics:
p-nitrophenyl-D-lactic acid is used as a diagnostic tool for [detecting and measuring enzyme levels in biological samples, aiding in the diagnosis of certain diseases].
Used in the Study of Metabolic Pathways:
p-nitrophenyl-D-lactic acid is used as a tracer molecule for [mapping and understanding the complex interactions within metabolic pathways].

Upstream product

• 56613-61-7 (R)-4-nitro-phenylalanine 
• 673-06-3 D-(R)-phenylalanine 

Downstream Products

• 66592-67-4 D-(+)-p-Aminophenyl-milchsaeure 
• 33173-39-6 (R)-ethyl 2-hydroxy-3-(4-nitrophenyl)propanoate 
• 154733-50-3 (R)-benzyl 3-(4-aminophenyl)-2-hydroxypropanoate 

Relevant academic research and scientific papers

ENDOPARASITIC DEPSIPEPTIDES

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof (1) wherein each of R1, R2, R3, R4, L1, and L2, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.

ENDOPARASITIC DEPSIPEPTIDES

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R1, R2, R3, R4, L1, and L2 are as defined herein. The present invention also contemplates compositions, methods of treatment, and uses as a medicament to treat an animal for an endoparasitic infection with a Formula (1 ) compound.

Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity

PPARs are ligand-activated transcription factors that govern lipid and glucose homeostasis and play a central role in cardiovascular disease, obesity, and diabetes. Herein, we present screening results for a series of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives, some of which are potent PPARγ agonists as well as PPARα agonists. To investigate the binding modes of the most interesting derivatives into the PPARα and PPARγ binding clefts and evaluate their agonist activity, docking experiments, molecular dynamics simulations, and MM-PBSA analysis were performed.