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Relevant academic research and scientific papers

Process for preparing 2-thio-2-substituted-alkanoic acid derivatives

A process for preparing a 2-thio-2-substituted-alkanoic acid derivative represented by the formula (I) STR1 wherein A, R, R3 and R4 are as defined hereinafter, which comprises condensing an aldehyde compound of the formula (V) wherein A is as defined hereinafter, with a haloform of the formula CHX3 wherein X is as defined hereinafter and a mercaptan compound of the formula (IV) wherein R3 is as defined hereinafter, in the presence of a base to produce a 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) STR2 wherein A and R3 are as defined hereinafter, and reacting the resulting 2-(arylthio or alkylthio)-2-substituted-acetic acid of the formula (III) with an alkylating agent represented by the formula (II) wherein R and Z are as defined hereinafter, in the presence of at least 2 mols of a base per mol of the 2-(arylthio or alkylthio)-2-substituted-acetic acid, to form the compound of the formula (I) wherein R4 represents a hydrogen atom and, optionally, converting the resulting compound to the compound of the formula (I) wherein R4 represents an alkyl group by esterification.

Process for preparing aromatic acetic acid

There are disclosed processes for preparing an aromatic acetic acid by the reaction of an aromatic aldehyde with a combination of a trihalomethane and an alkanethiol, and by the reaction of an alcohol derivative (2,2,2-trihalo-1-arylethanol) with an alkanethiol, in the presence of a base in a mixed medium of water and an aprotic polar solvent.

Process for preparing thiophene derivatives and thiophene derivatives obtained thereby

Process for the preparation of a series of thiophene derivatives, from which 2-thiopheneacetic acid derivatives can easily be prepared, in high yields and selectivity by using substituted or unsubstituted thiophenes as the starting materials by easy operations. 2-Thiopheneacetic acid derivatives are very useful compounds as the chemical modifier of penicillin and cephalosporin. Novel compounds, i.e. α-arylthio-2-thiopheneacetic acids are also disclosed. These compounds are useful as the intermediates of the synthesis of 2-thiopheneacetic acids.