686747-19-3 Usage
Uses
Used in Pharmaceutical Industry:
1H-Indole-3-carboxylic acid, 5-amino, methylester (9CI) is utilized as a key building block for the synthesis of biologically active compounds due to its unique structure and functional groups. It serves as a precursor for the development of potential antiviral, antitumor, and anti-inflammatory agents, contributing to the advancement of novel therapeutics.
Used in Antiviral Applications:
In the field of antiviral research, 1H-Indole-3-carboxylic acid, 5-amino, methylester (9CI) is employed for its potential to inhibit viral replication and pathogenesis, offering a promising avenue for the creation of new antiviral drugs.
Used in Antitumor Applications:
1H-Indole-3-carboxylicacid,5-amino-,methylester(9CI) is also used in antitumor applications, where it may contribute to the development of drugs that target and inhibit the growth of cancer cells, providing a new approach to cancer treatment.
Used in Anti-Inflammatory Applications:
1H-Indole-3-carboxylic acid, 5-amino, methylester (9CI) is applied in the synthesis of anti-inflammatory agents, potentially aiding in the management of inflammation-related conditions by modulating the immune response and reducing inflammation.
Used in Antimicrobial Applications:
Due to its antimicrobial properties, 1H-Indole-3-carboxylicacid,5-amino-,methylester(9CI) is used in the development of new antimicrobial agents, which can combat resistant bacterial strains and contribute to the treatment of various infections.
Used in Antioxidant Applications:
The antioxidant capabilities of 1H-Indole-3-carboxylic acid, 5-amino, methylester (9CI) make it a valuable component in the formulation of antioxidants, which can protect cells from oxidative damage and have potential applications in the prevention and treatment of various diseases associated with oxidative stress.
Used in Synthetic Chemistry:
As a synthetic intermediate, 1H-Indole-3-carboxylic acid, 5-amino, methylester (9CI) is used in diverse chemical transformations, enabling the synthesis of a broad spectrum of compounds for various applications across different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 686747-19-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,6,7,4 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 686747-19:
(8*6)+(7*8)+(6*6)+(5*7)+(4*4)+(3*7)+(2*1)+(1*9)=223
223 % 10 = 3
So 686747-19-3 is a valid CAS Registry Number.
686747-19-3Relevant academic research and scientific papers
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1
Castellano, Sabrina,Spannhoff, Astrid,Milite, Ciro,Dal Piaz, Fabrizio,Cheng, Donghang,Tosco, Alessandra,Viviano, Monica,Yamani, Abdellah,Cianciulli, Agostino,Sala, Marina,Cura, Vincent,Cavarelli, Jean,Novellino, Ettore,Mai, Antonello,Bedford, Mark T.,Sbardella, Gianluca
, p. 9875 - 9890 (2013/01/16)
Arginine methylation is a common post-translational modification that is crucial in modulating gene expression at multiple critical levels. The arginine methyltransferases (PRMTs) are envisaged as promising druggable targets, but their role in physiological and pathological pathways is far from being clear due to the limited number of modulators reported to date. In this effort, enzyme activators can be invaluable tools useful as gain-of-function reagents to interrogate the biological roles in cells and in vivo of PRMTs. Yet the identification of such molecules is rarely pursued. Herein we describe a series of aryl ureido acetamido indole carboxylates (dubbed "uracandolates"), able to increase the methylation of histone (H3) or nonhistone (polyadenylate-binding protein 1, PABP1) substrates induced by coactivator-associated arginine methyltransferase 1 (CARM1), both in in vitro and cellular settings. To the best of our knowledge, this is the first report of compounds acting as CARM1 activators.
INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2
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Page/Page column 111; 112, (2010/02/06)
There is provided a compound having Formula (I): wherein one of R1 and R2 is a group of the Formula (a), wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group (Formula (a)) wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.
