686753-00-4

Upstream product

• 499-06-9 3,5-dimethylbenzoic acid 
• 141-43-5 ethanolamine 
• 22445-42-7 3,5-dimethylbenzonitrile 
• 6613-44-1 3,5-dimethylbenzoyl chloride 
• 767300-31-2 N-(2-hydroxy-ethyl)-3,5-dimethyl-benzamide 

Downstream Products

• 686753-01-5 2-(3,5-dimethylphenyl)oxazole 
• 349453-71-0 2,4-dimethyl-6-(oxazol-2-yl)aniline 
• 686753-02-6 2-(3,5-dimethyl-2-nitrophenyl)oxazole 

Relevant academic research and scientific papers

Highly efficient synthesis of β-nitrate ester carboxamides through the ring-opening of 2-oxazolines

A novel method for the synthesis of β-nitrate ester carboxamides using non-corrosive tert-butyl nitrite (TBN) as the nitro source and easily available oxygen as the oxidant has been developed. Variously substituted 2-oxazolines were efficiently ring-opened to deliver the corresponding products in excellent yields. Notably, this reaction provides fast access to pharmaceuticals such as nicorandil.

An efficient, eco-friendly, one-pot protocol for the synthesis of 2-oxazolines promoted by ionic liquid/indium chloride

2-Oxazolines have been synthesized using a solventless ionic liquid melt in good yields at ambient temperatures. The efficiency of various Lewis acid catalysts for the same reaction has been compared. The effectiveness of different alkyl chains in the ionic liquids for the synthesis of oxazolines has been studied and a butylmethylimidazolinium chloride/indium chloride melt has been found to be the best media for promoting the reaction. CSIRO 2006.

Discovery, Modeling, and Human Pharmacokinetics of N-(2-Acetyl-4,6-dimethylphenyl)-3-(3,4-dimethylisoxazol-5-ylsulfamoyl) -thiophene-2-carboxamide (TBC3711), a Second Generation, ETA Selective, and Orally Bioavailable Endothelin Antagonist

Sitaxsentan (1) (Wu et al. J. Med. Chem. 1997, 40, 1690) is our first endothelin antagonist being evaluated in clinical trials. It has demonstrated biological effects in an acute hemodynamic study in CHF (Givertz et al. Circulation 2000, 101, 2922), an op