68676-76-6Relevant academic research and scientific papers
Organoaluminum-promoted cycloaddition of trialkylsilylketene with aldehydes: A new, stereoselectie approach to cis-2-oxetanones and 2(Z)-alkenoic acids
Concepcion,Maruoka,Yamamoto
, p. 4011 - 4020 (2007/10/02)
The exceptionally bulky methylaluminum bis(4-bromo-2,6-di-tert-butylphenoxide) (MABR) can be successfully utilized as a highly efficient Lewis acid for achieving high stereoselectivity in the cycloaddition of trialkylsilylketene with aldehydes. This method serves as a highly effective route to the synthesis of cis-2-oxetanones from saturated aldehydes, and the synthesis of 2(Z)-alkenoic acids from aromatic and α,β-unsaturated aldehydes.
