686766-52-9

Usage

Explanation

The full name of the compound, which describes its structure and composition.

Explanation

The compound is derived from 1,2-pyrrolidinedicarboxylic acid by forming an ester linkage.

Explanation

The parent compound from which the ester derivative is formed.

Explanation

The ester group attached to the parent compound, which is derived from 1,1-dimethylethyl alcohol.

Explanation

A 2-fluorophenoxy group is attached to the ester moiety, which may impart specific chemical and biological properties to the molecule.

Explanation

The stereochemistry of the compound, indicating the spatial arrangement of the substituents around the chiral centers.

Explanation

The compound is commonly used as a precursor in the synthesis of pharmaceuticals and agrochemicals due to its unique structure and properties.

Explanation

The compound's specific properties and stereochemistry make it a promising candidate for further research and development in the field of medicinal chemistry and drug development.

Type of Compound

Ester derivative

Parent Compound

1,2-Pyrrolidinedicarboxylic acid

Ester Moiety

1-(1,1-dimethylethyl) ester

Substituent

4-(2-fluorophenoxy) group

Stereochemistry

(2S,4S)-

Applications

Pharmaceutical and agrochemical synthesis

Potential Applications

Medicinal chemistry and drug development

Upstream product

• 686766-51-8 4-(2-fluoro-phenoxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant academic research and scientific papers

NOVEL COMPOUNDS OF PROLINE AND MORPHOLINE DERIVATIVES

The present invention relates to compounds with the formulas (I), (II), and (III), or a pharmaceutically acceptable salt thereof: wherein T is a (4 to 10)-membered heterocyclyl selected from the group consisting of and wherein R1. R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formulas (I), (II), and (III) and methods of treating a condition that is mediated by the modulation of the 11-β-hsd-1 enzyme, the method comprising administering to a mammal an effective amount of a compound of formulas (I), (II), and (III).

PROLINE DERIVATIVES HAVING AFFINITY FOR THE CALCIUM CHANNEL ALPHA-2-DELTA SUBUNIT

The compounds of formula (I) or a pharmaceutically acceptable salt, solvate or pro-drug thereof, are proline derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, fibromyalgia, arthritis, neuropathalogical disorders, sleep disorders, visceral pain disorders and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included. Wherein either X is O, S, NH or CH2 and Y is CH2 or a direct bond, or Y is O, S or NH and X is CH2; and R is a 3-12 membered cycloalkyl, 4-12 membered heterocycloalkyl, heteroaryl or aryl, where any ring may be optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, nitro, amino, hydroxycarbonyl, Cl-C6 alkyl, Cl-C6 alkenyl, CI-C6 alkynyl, Cl-C6 alkoxy, hydroxyC,-C6 alkyl, Cl-C6 alkoxyC,-C6 alkyl, perfluoro Cl-C6 alkyl, perfluoroC,-C6 alkoxy, Cl-C6 alkylamino, di- C1-C6 alkylamino, aminoC1-C6 alkyl, Cl-C6 alkylaminoC,-C6 alkyl, di-Cl-C6 alkylaminoC,-C6 alkyl, CI-C6acyl, C1-C6acyloxy, Cl-C6acyloxyC,-C6 alkyl, Cl-C6 acylamino, Cl-C6 alkylthio, C1-C6 alkylthiocarbonyl, C1-C6 alkylthioxo, C1-C6 alkoxycarbonyl, Cl-C6 alkylsulfonyl, C1-C6 alkylsulfonylamino, aminosulfonyl, Cl-C6 alkylaminosulfonyl, di-Cl-C6 alkylaminosulfonyl, 3-8 membered cycloalkyl, 4-8 membered heterocycloalkyl, phenyl and monocyclic heteroaryl; or a pharmaceutically acceptable salt, solvate or pro-drug thereof.