686766-86-9

Upstream product

• 603-35-0 triphenylphosphine 
• 113211-94-2 2,3-difluorobenzyl bromide 

Downstream Products

• 1429328-26-6 (Z)-2-(2,3-difluorostyryl)-3,4-dihydro-2H-pyran 
• 1429328-52-8 (Z)-6-(2,3-difluorostyryl)-5,6-dihydro-2H-pyran-2-one 
• 1429328-53-9 (Z)-6-(tert-butylperoxy)-2-(2,3-difluorostyryl)-3,6-dihydro-2H-pyran 

Relevant academic research and scientific papers

Design, synthesis, in vitro cytotoxicity evaluation and structure-activity relationship of Goniothalamin analogs

A series of six/five member (E/Z)-Goniothalamin analogs were synthesized from commercially available (3,4-dihydro-2H-pyran-2-yl)methanol/5- (hydroxymethyl)dihydrofuran-2(3H)-one in three steps with good to moderate overall yields and their cytotoxicity against lymphoblastic leukemic T cell line (Jurkat E6.1) have been evaluated. Among the synthesized analogs, (Z)-Goniothalamin appeared to be the most active in cytotoxicity (IC 50 = 12 μM). Structure-activity relationship study indicates that introducing substituent in phenyl ring or replacing phenyl ring by pyridine/naphthalene, or decreasing the ring size of lactones (from six to five member) do not increase the cytotoxicity.