686776-23-8

Upstream product

• 488-17-5 3-methylbenzene-1,2-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 244126-22-5 toluene-4-sulfonic acid 2-hydroxy-3-methyl-phenyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 686776-24-9 toluene-4-sulfonic acid 5-formyl-2-methoxy-3-methyl-phenyl ester 
• 686776-20-5 2-amino-3-[4-methoxy-3-methyl-5-(toluene-4-sulfonyloxy)-phenyl]-propionic acid tert-butyl ester 
• 686776-29-4 [(S)-2-(3-Allyloxy-4-methoxy-5-methyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid allyl ester 
• 686776-21-6 [(S)-2-(3-Allyloxy-4-methoxy-5-methyl-phenyl)-1-formyl-ethyl]-carbamic acid allyl ester 
• 686776-28-3 [(S)-2-(3-Hydroxy-4-methoxy-5-methyl-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid allyl ester 
• 686776-25-0 toluene-4-sulfonic acid 5-hydroxymethyl-2-methoxy-3-methyl-phenyl ester 
• 686776-22-7 3-tolylsulfonyloxy-4-methoxy-5-methyl benzyl bromide 
• 686776-27-2 (S)-5-(2-amino-3-hydroxypropyl)-2-methoxy-3-methylphenol 
• 854022-33-6 C₆₉H₈₃Cl₃N₄O₁₆SSi 
• 854022-04-1 C₆₆H₇₃Cl₃N₄O₁₆S 
• 854022-31-4 {2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester 
• 854021-99-1 [(1S,2R)-2-((5R,7R,10R)-11-Allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-(3-allyloxy-4-methoxy-5-methyl-benzyl)-2-cyano-ethyl]-carbamic acid allyl ester 

Relevant academic research and scientific papers

A short enantioselective synthesis of protected L-3-hydroxy-4-methoxy-5- methyl phenylalanine and its corresponding aldehyde - A common subunit of ecteinascidin-743, safracin and congeners

An asymmetric synthesis of appropriately protected L-3-hydroxy-4-methoxy-5- methyl phenylalanine from 3-methyl-catechol is described featuring a key enantioselective alkylation step.

Intermediate and process of preparation of ecteinascidin using such intermediate

The present invention concerns an intermediate of the following formula I in which R1 and R2 represent independently of each other a C1-C12 alkyl group, a (C1-C12 alkoxy)carbonyl group, opt

Synthetic studies toward ecteinascidin 743

An efficient synthesis of a fully functionalized tetracycle (A-B-C-H) 7 containing a 1,4-bridged 10-membered lactone was developed. Phenolic aldol condensation between 2-methylsesamol (15) and Garner's aldehyde provided the protected amino diol 16, which