68701-46-2

Upstream product

• 19936-11-9 N-(4-cyclopropylphenyl)acetamide 
• 68701-45-1 N-(2-bromo-4-cyclopropylphenyl)acetamide 

Downstream Products

• 68701-47-3 2-amino-5-cyclopropylbenzoic acid 
• 84118-05-8 6-cyclopropyl-2-methylquinazolin-4-(3H)-one 

Relevant academic research and scientific papers

(E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acids, a new series of antiallergy agents

A series of substituted (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acids was prepared and evaluated in the rat passive cutaneous anaphylaxis (PCA) test for antiallergic activity. Alkoxy, alkylthio, and isopropyl substituents at the 6- or 8-positions provided highly potent compounds. Conversion to the Z isomer, reduction of the side chain double bond, or reduction of the quinazoline ring resulted in substantial loss of activity. Among the analogues that exhibited oral activity in the PCA test, (E)-3-[6-(methylthio)-4-oxo-4H-quinazolin-3-yl]-2-propenoic acid was the most potent.

Substituted 11-oxo-11H-pyrido[2,1-b]quinazolines and method of inhibiting allergic reactions with them

Pyrido[2,1-b]quinazolines of the formulas STR1 wherein R1, R1 ', R2, R2 ', R3, R3 ', R4 and R10 are as hereinafter set forth, and processes for the preparation thereof