68715-65-1

Basic information

• Product Name: 6-(1-methylhydrazinyl)-9-pentofuranosyl-9H-purine
• CAS NO: 68715-65-1
• Molecular Formula: C₁₁H₁₆N₆O₄
• Molecular Weight: 296.2825
• Mol File: 68715-65-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 655.2°C at 760 mmHg
• Flash Point: 350.1°C
• Density: 1.92g/cm³
• Vapor Pressure: 4.61E-18mmHg at 25°C
• Refractive Index: 1.84
• CAS DataBase Reference: 6-(1-methylhydrazinyl)-9-pentofuranosyl-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(1-methylhydrazinyl)-9-pentofuranosyl-9H-purine(68715-65-1)
• EPA Substance Registry System: 6-(1-methylhydrazinyl)-9-pentofuranosyl-9H-purine(68715-65-1)

Safety Data

• Hazardous Substances Data: 68715-65-1(Hazardous Substances Data)

Upstream product

• 2004-06-0 6-Chloropurine riboside 
• 60-34-4 methylhydrazine 
• 14426-53-0 6-Iodo-purine riboside 

Relevant articles and documents

6-Iodopurine as a Versatile Building Block for RNA Purine Architecture Modifications

Natural modified bases in RNA were found to be indispensable for basic biological processes. In addition, artificial RNA modifications have been a versatile toolbox for the study of RNA interference, structure, and dynamics. Here, we present a chemical method for the facile synthesis of RNA containing C6-modified purine. 6-Iodopurine, as a postsynthetic building block with high reactivity, was used for metal-free construction of C-N, C-O, and C-S bonds under mild conditions and C-C bond formation by Suzuki-Miyaura cross-coupling. Our strategy provides a convenient approach for the synthesis of various RNA modifications, especially for oligonucleotides containing specific structures.

Anti-malarial activity of N6-modified purine analogues

Plasmodium falciparum causes one of the deadliest forms of malaria and resistance to the currently available drugs makes it imperative to develop new, safe and potent drugs. Parasites such as P. falciparum are unable to synthesise purines de novo and to t