6872-73-7 Usage
Anticancer Research
Different sources of media describe the Anticancer Research of 6872-73-7 differently. You can refer to the following data:
1. Alkaloids are a class of nitrogenous organic compounds of plant origin that havedistinct physiological actions on humans. Coralyne [(C22H22O4N+) 5, 6, 7, 8, 13, 13ahexadehydro-8-methyl-2, 3, 10, 11-tetramethoxy berberinium] is a heterocyclic analogof protoberberine alkaloid with antileukaemic activity and relatively high DNA/RNA-binding and intercalative potential compared to other isoquinoline compounds.Kumari et al. (2017) reported that treatment of coralyne in combination with paclitaxel(conventional chemotherapeutic drug) may exhibit synergistic effect on inhibitionof proliferation, migration and induction of apoptosis in MDA-MB-231 TNBCcells. They reported that coralyne (10 μM) in combination with paclitaxel (0.1 μM)effectively inhibits MDA-MB-231 cell proliferation and migration at 48 h time point.Further, the combination altered the gene expression of the apoptotic mediators Baxand Bcl-2 (Kumari et al. 2017). Their study revealed that low doses of coralyne andpaclitaxel showed promising therapeutic potential against TNBC cells.
2. Coralyne inhibits cell proliferationin combination with paclitaxel.The combination inhibits cancercell migration and inducesapoptosis.Kumariet al. (2017)
Check Digit Verification of cas no
The CAS Registry Mumber 6872-73-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,7 and 2 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6872-73:
(6*6)+(5*8)+(4*7)+(3*2)+(2*7)+(1*3)=127
127 % 10 = 7
So 6872-73-7 is a valid CAS Registry Number.
InChI:InChI=1/C22H22NO4.C2H4O5S/c1-13-16-11-21(26-4)20(25-3)10-15(16)8-18-17-12-22(27-5)19(24-2)9-14(17)6-7-23(13)18;3-2(4)1-8(5,6)7/h6-12H,1-5H3;1H2,(H,3,4)(H,5,6,7)/q+1;/p-1
6872-73-7Relevant academic research and scientific papers
Experimental antileukemic agents. Coralyne, analogs, and related compounds
Zee Cheng,Paull,Cheng
, p. 347 - 351 (2007/10/05)
Analogs of the antileukemic alkaloid coralyne and related compounds were synthesized for structure activity study. It was found that among the 8 alkyl substituted and the 8 unsubstituted compounds, the 8 ethyl homolog demonstrates better antileukemic activity against leukemias L1210 and P388 in mice than the parent compound; the 8 propyl derivative is inactive, suggesting that both lipid solubility and steric effect are significant factors; the planarity and rigidity of molecules of this type are critical to activity; replacement of either or both o dimethoxy groups of coralyne by methylenedioxy groups causes a slight decrease in the antileukemic activity; interestingly, the two bis(methylenedioxy) analogs displayed activity in the KB cell culture system whereas the corresponding dimethoxy compounds are inactive; elimination of some methoxy groups of coralyne lowers, but does not completely abolish, the original activity; and activities of different salts are comparable but the acetosulfate salt is preferred because of its relatively higher solubility in water. Coralyne forms a stable complex with thymus DNA in vitro and exhibits reversible covalent hydration in water. The activity of coralyne against leukemia L1210 was shown to be schedule independent.
