68738-01-2

Upstream product

• 7732-18-5 water 
• 21050-13-5 bis(triphenylphosphine)iminium chloride 

Downstream Products

• 56791-54-9 bis(triphenylphosphine)iminium tetracarbonylhydridoferrate⁽⁰⁾ 
• 78362-94-4 {PPN}{HCr(CO)5} 
• 78419-12-2 CH₃CORe(H)(CO)4^(1-)*[(C₆H₅)3P]2N⁽¹⁺⁾=[(C₆H₅)3P]2N(CH₃CO)Re(H)(CO)4 

Relevant academic research and scientific papers

Catalysis of Radical Cyclizations from Alkyl Iodides under H2: Evidence for Electron Transfer from [CpV(CO)3H]-

Radical cyclizations are most often achieved with Bu3SnH in the presence of a radical initiator, but environmental considerations demand that alternative reagents be developed - ones that can serve as a synthetic equivalent to the hydrogen atom. We have revisited [CpV(CO)3H]-, a known replacement for Bu3SnH, and found that it can be used catalytically under H2 in the presence of a base. We have carried out tin-free catalytic radical cyclizations of alkyl iodide substrates. The reactions are atom-efficient, and the conditions are mild, with broad tolerance for functional groups. We have, for example, achieved the first 5-exo radical cyclization involving attack onto a vinyl chloride. We suggest that the radicals are generated by an initial electron transfer.