68747-36-4

Usage

Uses

Used in Pharmaceutical Industry:
(7-Hydroxy-8-methyl-2-oxo-2H-chromen-4-yl)-acetic acid is used as a potential therapeutic agent for various conditions due to its structural resemblance to natural coumarin compounds with known pharmacological activities. Its potential applications may include anti-inflammatory, anti-coagulant, and anti-cancer treatments.
Used in Drug Development:
In the field of drug development, (7-Hydroxy-8-methyl-2-oxo-2H-chromen-4-yl)-acetic acid serves as a promising candidate for the creation of novel pharmaceuticals. Its structural features and potential bioactivity make it a subject of interest for researchers aiming to develop new drugs with improved efficacy and safety profiles.
Used in Research and Development:
(7-Hydroxy-8-methyl-2-oxo-2H-chromen-4-yl)-acetic acid is utilized as a key compound in research and development for exploring its pharmacological properties and potential applications in medicine. Its study may lead to the discovery of new therapeutic approaches and the advancement of drug development strategies.

Upstream product

• 542-05-2 acetonedicarboxylic acid 
• 608-25-3 2-methylbenzene-1,3-diol 
• 714206-31-2 methyl 2-(7-hydroxy-8-methyl-2-oxochromen-4-yl)acetate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 

Downstream Products

• 251361-33-8 (7-hydroxy-8-methyl-2-oxo-2H-chromen-4-yl)-acetic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of 2-(2-oxo-2H-chromen-4-yl)acetamides as potent acetylcholinesterase inhibitors and molecular insights into binding interactions

Sixteen novel coumarin-based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04 ± 0.01 μM), noncompetitively inhibited AChE with a higher potency than tacrine and gala

Modified coumarins. 14. Synthesis of 7-hydroxy-[4,3′]dichromenyl-2, 2′-dione derivatives

New derivatives of 3-(2-oxochromen-4-yl)chromen-2-one, modified analogs of natural dicoumarins, were prepared from substituted coumarin-4-acetic acids.

Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose

A series of novobiocin-like coumarincarboxylic acids has been prepared bearing the L-rhamnosyl moiety as the sugar portion of the molecule. The similar DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates that L-rhamnose can effectively replace L-novoise. Introduction of alkyl side-chains at C-5 of coumarin leads to improved in vitro antibacterial properties in the novel series.