68755-42-0 Usage
Description
4-(Trifluoromethyl)-1-indanone, an organic compound with the chemical formula C10H7F3O, is a white solid known for its aromatic and ketonic properties. It is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. This versatile compound is valued in the field of organic chemistry due to its unique structure and reactivity, and it also serves as a research chemical in the development of new materials and drugs.
Uses
Used in Pharmaceutical Industry:
4-(Trifluoromethyl)-1-indanone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with improved properties.
Used in Organic Chemistry Research:
As a research chemical, 4-(Trifluoromethyl)-1-indanone is utilized in the exploration of new materials and compounds, enhancing the understanding of chemical reactions and processes.
Used in Organic Compound Synthesis:
4-(Trifluoromethyl)-1-indanone is employed as a building block in the synthesis of a wide range of organic compounds, leveraging its unique structure and reactivity to create novel molecules with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 68755-42-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,7,5 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 68755-42:
(7*6)+(6*8)+(5*7)+(4*5)+(3*5)+(2*4)+(1*2)=170
170 % 10 = 0
So 68755-42-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H7F3O/c11-10(12,13)8-3-1-2-7-6(8)4-5-9(7)14/h1-3H,4-5H2
68755-42-0Relevant articles and documents
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H- indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management
Gomtsyan, Arthur,Bayburt, Erol K.,Schmidt, Robert G.,Surowy, Carol S.,Honore, Prisca,Marsh, Kennan C.,Hannick, Steven M.,McDonald, Heath A.,Wetter, Jill M.,Sullivan, James P.,Jarvis, Michael F.,Faltynek, Connie R.,Lee, Chih-Hung
, p. 392 - 395 (2008/09/17)
Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here we report that replacement of substituted benzyl groups by an indan rigid moiety in a previously described N-indazole-N′-benzyl urea series led to a number of TRPV1 antagonists with significantly increased in vitro potency and enhanced drug-like properties. Extensive evaluation of pharmacological, pharmacokinetic, and toxicological properties of synthesized analogs resulted in identification of (R)-7 (ABT-102). Both the analgesic activity and drug-like properties of (R)-7 support its advancement into clinical pain trials.
Trifluoromethyl substituted 1-aminoindanes
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, (2008/06/13)
4(5 or 6 or 7)-Trifluoromethyl-1-aminoindanes, useful as inhibitors of N-methyl transferase.
