6876-50-2

Basic information

• Product Name: 3-methyl-N-(4-methylphenyl)butanamide
• Synonyms: 3-methyl-N-(4-methylphenyl)butanamide
• CAS NO: 6876-50-2
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.26948
• Mol File: 6876-50-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 339.1°Cat760mmHg
• Flash Point: 202.2°C
• Appearance: /
• Density: 1.013g/cm³
• Vapor Pressure: 9.43E-05mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 3-methyl-N-(4-methylphenyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-N-(4-methylphenyl)butanamide(6876-50-2)
• EPA Substance Registry System: 3-methyl-N-(4-methylphenyl)butanamide(6876-50-2)

Safety Data

• Hazardous Substances Data: 6876-50-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H17NO/c1-9(2)8-12(14)13-11-6-4-10(3)5-7-11/h4-7,9H,8H2,1-3H3,(H,13,14)

Upstream product

• 5674-02-2 2-methylpropylmagnesium chloride 
• 622-58-2 p-Tolylisocyanate 
• 60-29-7 diethyl ether 
• 108-64-5 Ethyl isovalerate 
• 14618-59-8 N-(tert-butoxycarbonyl)-4-methylaniline 
• 86065-10-3 O-allyl-N-(4-methylphenyl)carbamate 
• 7625-64-1 p-tolyl-carbamic acid benzyl ester 
• 106-49-0 p-toluidine 

Downstream Products

• 946769-13-7 isovaleric acid-(2-amino-4-methyl-anilide) 
• 432536-98-6 isovaleric acid-(4-methyl-2-nitro-anilide) 
• 352689-13-5 isovaleric acid-(2-bromo-4-methyl-anilide) 

Relevant articles and documents

Practical one-pot amidation of N -Alloc-, N -Boc-, and N -Cbz protected amines under mild conditions

A facile one-pot synthesis of amides from N-Alloc-, N-Boc-, and N-Cbz-protected amines has been described. The reactions involve the use of isocyanate intermediates, which are generated in situ in the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, to react with Grignard reagents to produce the corresponding amides. Using this reaction protocol, a variety of N-Alloc-, N-Boc-, and N-Cbz-protected aliphatic amines and aryl amines were efficiently converted to amides with high yields. This method is highly effective for the synthesis of amides and offers a promising approach for facile amidation.