68767-16-8

Usage

Uses

Used in Pharmaceutical Industry:
Benzeneacetic acid, a-methyl-4-[(2-oxocyclohexyl)methyl]is utilized as a decongestant in the pharmaceutical industry to treat nasal congestion caused by various conditions such as allergies, sinusitis, or the common cold. Its effectiveness in reducing swelling and congestion makes it a popular choice for over-the-counter cold and allergy medications.
Used in Regulatory Measures:
Due to its potential use in the illegal production of methamphetamine, Benzeneacetic acid, a-methyl-4-[(2-oxocyclohexyl)methyl]has become a regulated substance. This regulatory measure aims to curb the misuse of pseudoephedrine in the production of illicit drugs while ensuring its continued availability for legitimate medical purposes. As a result, it is often only available behind the pharmacy counter, with restrictions on the quantity that can be purchased within a given time frame.

Upstream product

• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 43153-03-3 2-(4-chloromethylphenyl)-propionic ethyl ester 
• 66342-64-1 ethyl 2-[4-(1-ethoxycarbonyl-2-oxocyclohexan-1-ylmethyl)phenyl]propionate 

Downstream Products

• 68767-22-6 2-(4-{2-[(E)-Hydroxyimino]-cyclohexylmethyl}-phenyl)-propionic acid 

Relevant academic research and scientific papers

Ophthalmic anti-inflammatory agents

Compounds of formula: STR1 (wherein R represents hydrogen or methyl, >A--B-- represents a >CH--CH2 -- or >C=CH-- group; >C--Z represents a >C=O or >CH--OH group; and n represents 1 or 2) and ophthalmically acceptable salts and esters thereof are useful as ophthalmic anti-inflammatory agents.

Synthesis and Antiinflammatory Activity of acetic Acids and Related Compounds

acetic acid derivatives and related compounds were synthesized to test their antiinflammatory and analgesic activities.Some of the compounds in this series were found to have good activity in the carrageenan edema test.Among them, sodium 2-phenyl>propionate dihydrate (15) and 2-phenyl>propionic acid (13b) showed potent analgesic and antiadjuvant arthritis activities with excellent antipyretic properties.

Substituted phenylacetic acid derivatives and process for the preparation thereof

4-(2-Oxo- or hydroxyimino-cycloalkan-1-ylmethyl)phenylacetic acid derivative and nontoxic pharmaceutically acceptable salt thereof are useful as an anti-inflammatory agent. The above 2-oxo-compound may be prepared by (a) hydrolyzing and decarboxylating 4-(1-alkoxycarbonyl-2-oxocycloalkan-1-ylmethyl)phenylacetic acid ester derivative or (b) reacting p-halomethylphenylacetic acid ester derivative with an enamine of cycloalkanone and hydrolyzing the resulting product. And further, the above 2-hydroxyimino-compound may be prepared by (c) reacting 4-(2-oxocycloalkan-1-ylmethyl)phenylacetic acid derivative (the product of process (a) or (b)) with hydroxylamine or (d) reacting a dilithium salt of cycloalkanone oxime with p-halomethyl- or p-sulfonyloxymethyl-phenylacetic acid ester derivative and hydrolyzing the resulting product.