68771-39-1

Basic information

• Product Name: 1-methyl-6-nitroquinolin-4(1H)-one
• CAS NO: 68771-39-1
• Molecular Formula: C₁₀H₈N₂O₃
• Molecular Weight: 204.1821
• Mol File: 68771-39-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 369.4°C at 760 mmHg
• Flash Point: 177.2°C
• Density: 1.37g/cm³
• Vapor Pressure: 1.19E-05mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 1-methyl-6-nitroquinolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-6-nitroquinolin-4(1H)-one(68771-39-1)
• EPA Substance Registry System: 1-methyl-6-nitroquinolin-4(1H)-one(68771-39-1)

Safety Data

• Hazardous Substances Data: 68771-39-1(Hazardous Substances Data)

Usage

Description

1-methyl-6-nitroquinolin-4(1H)-one is a chemical compound with the molecular formula C10H8N2O3. It is a derivative of quinoline and contains a nitro group and a methyl group. 1-methyl-6-nitroquinolin-4(1H)-one is known for its potential applications in the pharmaceutical and agrochemical industries due to its unique structure and properties.

Uses

Used in Pharmaceutical Industry:
1-methyl-6-nitroquinolin-4(1H)-one is used as an intermediate in the synthesis of pharmaceuticals for its potential antitumor and antimalarial properties. It has shown promising results in preclinical research, making it a valuable component in the development of novel drug candidates.
Used in Agrochemical Industry:
1-methyl-6-nitroquinolin-4(1H)-one is used as a building block in the synthesis of agrochemicals, contributing to the development of new bioactive compounds for agricultural applications.
Used in Organic Synthesis:
Due to its versatility, 1-methyl-6-nitroquinolin-4(1H)-one is also used as a key component in organic synthesis, allowing for the creation of a wide range of novel compounds with potential applications in various fields.

Upstream product

• 25063-45-0 2,2-dimethyl-5-(((4-nitrophenyl)amino)methylene)-1,3-dioxane-4,6-dione 
• 100-01-6 4-nitro-aniline 
• 21873-49-4 6-nitroquinoline-4(1H)-one 
• 74-88-4 methyl iodide 
• 103648-39-1 1-methyl-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 23432-42-0 4-hydroxy-6-nitro-quinoline 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1358531-84-6 1-methyl-6-nitro-3-(perfluorophenyl)quinolin-4(1H)-one 
• 188244-71-5 4-[Methanesulfonyloxy-(1-methyl-6-nitro-4-oxo-1,4-dihydro-quinolin-2-yl)-methyl]-3-methoxy-benzoic acid methyl ester 
• 195433-23-9 6-cyclopentyloxycarbonylamino-2-(2-methoxy-4-methoxycarbonylbenzyl)-1-methyl-4-oxo-1,4-dihydroquinoline 
• 195433-30-8 4-(6-Cyclopentyloxycarbonylamino-1-methyl-4-oxo-1,4-dihydro-quinolin-2-ylmethyl)-3-methoxy-benzoic acid 
• 188244-73-7 2-(2-methoxy-4-methoxycarbonylbenzyl)-1-methyl-6-nitro-4-oxo-1,4-dihydroquinoline 
• 188244-74-8 6-amino-2-(2-methoxy-4-methoxycarbonylbenzyl)-1-methyl-4-oxo-1,4-dihydroquinoline 
• 188244-70-4 2-(1-hydroxy-2-methoxy-4-methoxycarbonylbenzyl)-1-methyl-6-nitro-4-oxo-1,4-dihydroquinoline 

Relevant articles and documents

Method for the Fluorescent Detection of Nitroreductase Activity Using Nitro-Substituted Aromatic Compounds

A method utilising one or more fluorogenic probes, for the detection of nitroreductase activity. The non-fluorescent probes are reduced in the presence of nitroreductase to form fluorescent derivatives that may be detected using fluorescence spectroscopy. In particular, the method may be used to detect and/or identify a plurality of nitroreductase in a single test environment

Synthesis and pharmacological evaluation of new cysLT1 receptor antagonists

This paper describes the synthesis and pharmacological evaluation of three series of compounds 4a-b, 13a-k and 19, structurally related to the known potent cysLT1 receptor antagonists RG-12553, IC1-204219 and ONO-1078, respectively. The common structural feature of these new series is the presence of a 4-quinolone nucleus acting as a template for substitution of the aromatic nucleus present in the prototype antagonists. We describe the evolution of these series leading to antagonists with potency at nanomolar concentrations in vitro.