68771-39-1

Usage

Uses

Used in Pharmaceutical Industry:
1-methyl-6-nitroquinolin-4(1H)-one is used as an intermediate in the synthesis of pharmaceuticals for its potential antitumor and antimalarial properties. It has shown promising results in preclinical research, making it a valuable component in the development of novel drug candidates.
Used in Agrochemical Industry:
1-methyl-6-nitroquinolin-4(1H)-one is used as a building block in the synthesis of agrochemicals, contributing to the development of new bioactive compounds for agricultural applications.
Used in Organic Synthesis:
Due to its versatility, 1-methyl-6-nitroquinolin-4(1H)-one is also used as a key component in organic synthesis, allowing for the creation of a wide range of novel compounds with potential applications in various fields.

Upstream product

• 23432-42-0 4-hydroxy-6-nitro-quinoline 
• 77-78-1 dimethyl sulfate 
• 103648-39-1 1-methyl-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 21873-49-4 6-nitroquinoline-4(1H)-one 
• 74-88-4 methyl iodide 
• 100-01-6 4-nitro-aniline 
• 25063-45-0 2,2-dimethyl-5-(((4-nitrophenyl)amino)methylene)-1,3-dioxane-4,6-dione 

Downstream Products

• 188244-70-4 2-(1-hydroxy-2-methoxy-4-methoxycarbonylbenzyl)-1-methyl-6-nitro-4-oxo-1,4-dihydroquinoline 
• 188244-74-8 6-amino-2-(2-methoxy-4-methoxycarbonylbenzyl)-1-methyl-4-oxo-1,4-dihydroquinoline 
• 188244-73-7 2-(2-methoxy-4-methoxycarbonylbenzyl)-1-methyl-6-nitro-4-oxo-1,4-dihydroquinoline 
• 195433-30-8 4-(6-Cyclopentyloxycarbonylamino-1-methyl-4-oxo-1,4-dihydro-quinolin-2-ylmethyl)-3-methoxy-benzoic acid 
• 195433-23-9 6-cyclopentyloxycarbonylamino-2-(2-methoxy-4-methoxycarbonylbenzyl)-1-methyl-4-oxo-1,4-dihydroquinoline 
• 188244-71-5 4-[Methanesulfonyloxy-(1-methyl-6-nitro-4-oxo-1,4-dihydro-quinolin-2-yl)-methyl]-3-methoxy-benzoic acid methyl ester 
• 1358531-84-6 1-methyl-6-nitro-3-(perfluorophenyl)quinolin-4(1H)-one 

Relevant academic research and scientific papers

Method for the Fluorescent Detection of Nitroreductase Activity Using Nitro-Substituted Aromatic Compounds

A method utilising one or more fluorogenic probes, for the detection of nitroreductase activity. The non-fluorescent probes are reduced in the presence of nitroreductase to form fluorescent derivatives that may be detected using fluorescence spectroscopy. In particular, the method may be used to detect and/or identify a plurality of nitroreductase in a single test environment

Direct C-3-alkenylation of quinolones via palladium-catalyzed C-H functionalization

An unprecedented C-3-alkenylation of quinolones was reported through palladium-catalyzed C-H functionalization with 1% catalyst loading. This method provides an efficient route to a variety of new quinolone derivatives.

Synthesis and pharmacological evaluation of new cysLT1 receptor antagonists

This paper describes the synthesis and pharmacological evaluation of three series of compounds 4a-b, 13a-k and 19, structurally related to the known potent cysLT1 receptor antagonists RG-12553, IC1-204219 and ONO-1078, respectively. The common structural feature of these new series is the presence of a 4-quinolone nucleus acting as a template for substitution of the aromatic nucleus present in the prototype antagonists. We describe the evolution of these series leading to antagonists with potency at nanomolar concentrations in vitro.