68780-76-7

Upstream product

• 191847-32-2 tert-butyl (2-(6-iodobenzo[d][1,3]dioxol-5-yl)ethyl)carbamate 
• 191847-31-1 (2-benzo[1,3]dioxol-5-yl-ethyl) carbaminic acid tert-butyl ester 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 62059-59-0 methyl 6-formyl-2,3-dimethoxybenzoate 
• 519-05-1 opianic acid 
• 73563-23-2 3-bromo-6,7-dimethoxyphthalide 
• 569-31-3 meconin 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 68753-57-1 3-[1,3]dioxolo[4,5-g]isoquinolin-5-yl-6,7-dimethoxy-3H-isobenzofuran-1-one 
• 61128-71-0 2,3-dimethoxy-6-(5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline-5-carbonyl)-benzoic acid methyl ester; hydrochloride 

Relevant academic research and scientific papers

An Acid-Catalyzed Epoxide Ring-Opening/Transesterification Cascade Cyclization to Diastereoselective Syntheses of (±)-β-Noscapine and (±)-β-Hydrastine

An acid-catalyzed stereoselective epoxide ring-opening/intramolecular transesterification cascade cyclization reaction and N-Boc deprotection was found to be a successful strategy to construct the phthalide tetrahydroisoquinoline skeleton in one pot. Based on this strategy, the unified and highly diastereoselective routes for the total syntheses of (±)-β-Noscapine and (±)-β-Hydrastine were exploited.

A Pyrolytic Route to the Phthalide-Isoquinolines

Pyrolysis of 8,13-dioxo-14-methoxycanadine (5) yields methyl keto ester 11 (35percent), aromatic phthalide-isoquinoline 12 (15percent), and (+)-chilenine (13, 7percent).Methyl keto ester 11 can be reduced quantitatively to 12 with sodium borhydride.Cataly