68787-54-2

Upstream product

• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 

Downstream Products

• 82077-89-2 7-Oxo-2-phenyl-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidine-5-carboxylic acid hydrazide 
• 82077-94-9 C₁₅H₁₄N₆O₂S₂ 
• 82077-93-8 C₁₄H₁₂N₆O₂S₂ 

Relevant academic research and scientific papers

Synthesis of New Condensed Pyrimidine Systems: Reactions of Heterocyclic Amines with Acetylenic Esters

Several hitherto unreported 1,3,4-oxa/thiadiazolopyrimidin-7-ones (1 and 2) and thiazolopyrimidin-7-ones (3) have been synthesised by the reaction of 2-amino-1,3,4-oxa/thiadiazoles and 2-amino-4-arylthiazoles respectively with ethyl phenylpropiolate.The reaction of these amines with diethyl acetylenedicarboxylate furnishes the 7-oxo-5-carbethoxy derivatives (8-10).A similar reaction of 2-aminobenzothiazole with diethyl acetylenedicarboxylate affords 4-carbethoxypyrimidobenzothiazol-2(H)-one (7).To assign the structures of the 7-oxo derivatives the isomeric 5-oxo-7-carbethoxy derivatives (14) have also been synthesised by an unambiguous route.

SINTESI ED ATTIVITA ANTIMICOTICA DI DERIVATI DELL'1,3,4-TIADIAZOLOPIRIMIDONE

As a continuation of previous research designed to obtain derivatives of 1,3,4-thiadiazole of pharmacological interest, some derivatives of 1,3,4-thiadiazolepyrimidin-5-one and isomeric 7-one were prepared.The fungistatic activity of the products was tested in vitro against the following: Candida albicans, Candida parapsilosis, Candida tropicalis, Cryptococcus neoformans and Trichophyton rubrum.No relevant antifungal activity was observed for any of the compounds examined.

Studies on Reactive Intermediates. Part I. An Approach to the Synthesis of 2-Phenyl-7-carbethoxy-5H-1,3,4-thiadiazolopyrimidin-5-one

2-Phenyltetrazolo-1,3,4-thiadiazole (4), in its azido form, reacted with diethyl fumarate and diethyl maleate to give 2-phenyl-7-carbethoxy-5H-1,3,4-thiadiazolopyrimidin-5-one (5).To assign the structure of compound 5, 2-phenyl-5-carbethoxy-