68797-30-8

Basic information

• Product Name: ()-1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
• Synonyms: 4H-imidazole, 4-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-; 4-{2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-4H-imidazole
• CAS NO: 68797-30-8
• Molecular Formula: C₁₈H₁₅Cl₃N₂O
• Molecular Weight: 381.6835
• EINECS: 272-294-0
• Mol File: 68797-30-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 482.9°C at 760 mmHg
• Flash Point: 245.9°C
• Density: 1.36g/cm³
• Vapor Pressure: 5.15E-09mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: ()-1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: ()-1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole(68797-30-8)
• EPA Substance Registry System: ()-1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole(68797-30-8)

Safety Data

• Hazardous Substances Data: 68797-30-8(Hazardous Substances Data)

Usage

General Description

The chemical compound "()-1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole" is an antifungal agent that belongs to the class of imidazole derivatives. It functions by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting their structure and function. ()-1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole is commonly used in the treatment of fungal infections such as athlete's foot, ringworm, and jock itch. It is available in various forms, including topical creams, powders, and sprays for external use, as well as oral capsules and solutions for systemic infections. However, it should be noted that this compound may cause adverse effects and interactions with other medications, so it should be used under the supervision of a healthcare professional.

Upstream product

• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 
• 24155-42-8 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol 
• 2631-72-3 2,4-dichlorophenacyl bromide 
• 46503-52-0 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone 
• 4252-78-2 2,2',4'-trichloroacetophenone 

Downstream Products

• 57265-22-2 1-[2,4-Dichloro-β-(p-chlorobenzyloxy)phenethyl]-3-(p-fluorophenacyl)imidazolium chloride 
• 73094-37-8 (S)-1-(2-((4-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole 
• 73094-39-0 (R)-1-[2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole 

Relevant articles and documents

Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease

In our endeavor towards the development of potent multi-target ligands for the treatment of Alzheimer's disease, miconazole was identified to show BuChE-IDO1 dual-target inhibitory effects. Morris water maze test indicated that miconazole obviously ameliorated the cognitive function impaired by scopolamine. Furthermore, it showed good safety in primary hepatotoxicity evaluation. Based on these results, we designed, synthesized, and evaluated a series of miconazole derivatives as BuChE-IDO1 dual-target inhibitors. Out of the 12 compounds, 5i and 5j exhibited the best potency in enzymatic evaluation, thus were selected for subsequent behavioral study, in which the two compounds exerted much improved effect than tacrine. Meanwhile, 5i and 5j displayed no apparent hepatotoxicity. The results suggest that miconazole analogue offers an attractive starting point for further development of new BuChE-IDO1 dual-target inhibitors against Alzheimer's disease.