687995-79-5Relevant academic research and scientific papers
Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase
Cumming, John G.,McKenzie, Caroline L.,Bowden, Stuart G.,Campbell, Douglas,Masters, David J.,Breed, Jason,Jewsbury, Philip J.
, p. 5389 - 5394 (2004)
SAR studies led to the identification of 4-(3-benzoylamino-6-methyl- anilino)quinazolines as potent and selective inhibitors of p38 MAP kinase. Further optimisation led to the identification of a series of 4-(3-benzoylamino-6-methyl-anilino)pyrimidines as potent inhibitors of the p38 MAP kinase signalling pathway in vitro and in vivo. SAR studies led to the identification of 4-(3-benzoylamino-6-methyl-anilino)quinazolines as potent and selective inhibitors of p38 MAP kinase. Further optimisation led to the identification of a series of 4-(3-benzoylamino-6-methyl-anilino)pyrimidines as potent inhibitors of the p38 MAP kinase signalling pathway in vitro and in vivo.
