688035-62-3Relevant academic research and scientific papers
Syntheses and biological evaluation of ring-C modified colchicine analogs
Yang, Baiyuan,Zhu, Zhiqing C.,Goodson, Holly V.,Miller, Marvin J.
scheme or table, p. 3831 - 3833 (2010/08/20)
Ring-C modified alkaloids were synthesized from colchicine using iminonitroso Diels-Alder reactions in a highly regio- and stereoselective fashion. Several analogs exhibited cytotoxic activity similar to that of colchicine itself against PC-3 and MCF-7 cancer cell lines, by serving as prodrugs of colchicine through retro Diels-Alder reactions under the assayed conditions. In vitro microtubule polymerization assays indicated that these modifications affected their interaction with tubulin.
