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Upstream product

• 696-62-8 para-iodoanisole 
• 622-37-7 Phenyl azide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 32117-52-5 1-(1-(4-methoxyphenyl)ethylidene)-2-tosylhydrazine 
• 62-53-3 aniline 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 591-50-4 iodobenzene 
• 768-60-5 4-methoxyphenylacetylen 
• 108-86-1 bromobenzene 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 98-80-6 phenylboronic acid 
• 369-57-3 benzenediazonium tetrafluoroborate 

Relevant academic research and scientific papers

CuO–NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level

The unification of CuCl2·2H2O and NiCl2·6H2O with the support of graphitic carbon nitride yielded to form an efficient, synergistic, bimetallic nano-catalyst CuO–NiO@g-C3N4. FT-IR, SEM, TEM

A ferrocene functionalized Schiff base containing Cu(ii) complex: Synthesis, characterization and parts-per-million level catalysis for azide alkyne cycloaddition

Atom economy is one of the major factors in developing catalysis chemistry. Using the minimum amount of catalyst to obtain the maximum product yield is of the utmost priority in catalysis, which drives us to use parts-per-million (ppm) levels of catalyst

Iodine-mediated C-N and N-N bond formation: A facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions

A novel strategy towards the synthesis of 1,4-disubstituted 1,2,3-triazoles via C-N and N-N bond formation has been demonstrated under transition metal-free and azide-free conditions. These 1,2,3-triazoles were obtained in a regioselective manner from commercially available anilines, aryl alkenes/aryl alkynes and N-tosylhydrazines using I2 under O2 atmosphere. Broad substrate scope, milder reaction conditions, good to moderate yields and clean protocol are the notable features of the method. Moreover, this protocol is amenable for the generation of a library of medicinally important key building blocks.

Hyperbranched polyethylenimine-supported copper(II) ions as a macroliganted homogenous catalyst for strict click reactions of azides and alkynes in water

Loading hyperbranched polyethylenimine (PEI) with copper(II) ions leads to the formation of a new water-soluble metallodendritic polymer Cu(II)-PEI that has been found to effectively catalyze the clickable azide-alkyne [3 + 2] cycloaddition reactions in w

Application of two magnetic nanoparticle-supported copper(I) catalysts for the synthesis of triazole derivatives

Catalytic performance of two magnetically recoverable copper(I) complexes is reported for the synthesis of 1,2,3-triazole derivatives. Boronic acids and alkyl halides, in the presence of either catalyst, react with terminal alkynes and NaN3, fo

Method for preparing 1,2,3-triazole compound by heterogeneous copper catalysis in one pot

The invention relates to a method for preparing a 1-aryl-4-substituted-1,2,3-triazole compound shown as a formula (II). The method comprises the following steps: mixing arylboronic acid (1), NaN3, a heterogeneous copper catalyst and solvent water, performing a stirring reaction at 25-60 DEG C for 4-8 hours, performing TLC (thin-layer chromatography) monitoring till the arylboronic acid (1) is completely converted, replacing air in the reaction system by using N2, adding a terminal alkyne (2), performing a reaction at 40-80 DEG C for 6-10 hours under the protection of N2, and performing post-treatment on the reaction solution to obtain a product (II). By adopting the preparation method, Cu-coated SBA-15-PTAA is used as a catalyst, a series of 1-aryl-4-substituted-1,2,3-triazole compounds are prepared through a one-pot Chan-Lam/Click series method without additionally adding a reducing agent, the developed catalytic method is green, safe and economical, the amount of three wastes (wastegas, waste water and industrial residue) is small, the yield of a target product is high, and the substrate application range is wide.

Waste-minimised copper-catalysed azide-alkyne cycloaddition in Polarclean as a reusable and safe reaction medium

Herein we report the first example of a generally useful organic reaction, namely the copper-catalysed azide-alkyne cycloaddition, performed in a Polarclean/water mixture as a reaction medium. The process is very efficient, affording in 24 out of the 26 tested cases the desired triazole in quantitative yields. Product isolation is also very convenient, since the triazoles either precipitate or form a separate liquid phase, without the need to perform chromatographic separations. Moreover, since the metal catalyst is retained in the Polarclean/water phase, the catalyst/reaction medium can be easily reused for consecutive reaction runs, without an apparent loss in efficiency. This methodology is associated with very limited waste production, as evidenced by calculated E-factors in the range 2.6-3.7.

A method for preparing ionic liquid in 1, 2, 3 - triazole class is the compound of the method

The invention discloses a method for preparing 1, 2, 3-triazole type compounds in ion liquid. The method includes steps of firstly, dissolving CuSO4.5H2O in water under room temperature, adding Zn granules, dripping hydrochloric acid solution to dissolve excessive Zn, allowing for reaction until no bubbles are generated, filtering, and washing filter cake with hydrochloric acid to obtain nano-copper catalysts; secondly, adding the nano-copper catalysts into the ion liquid, adding end group alkyne compounds and trinitride, stirring under room temperature for reaction to separate out solids, adding appropriate amount of diethyl ether, filtering, washing filter cake to obtain nano-copper catalysts for recycling, and purifying filtrate to obtain the 1, 2, 3-triazole type compounds. The method has the advantages that the nano-copper catalysts are simple to prepare, low in use amount, efficient and recyclable, traditional organic solvents are replaced by the ion liquid, and the method is environmental friendly.

A one-pot, copper-catalyzed azidation/click reaction of aryl and heteroaryl bromides in an environmentally friendly deep eutectic solvent

In an effort to avoid the hazards of isolating and handling azides in click chemistry, many groups have turned to in situ generation of azides from halide precursors. This option is readily accomplished for alkyl azides, but is more challenging for aryl a

[bmim]PF6/KOH: A recyclable catalytic system for an azide–arylacetaldehyde [3 + 2] cycloaddition

A fast and green protocol for the synthesis of 1,4-disubstituted 1,2,3-triazoles from azides and arylacetaldehydes at room temperature was developed using [bmim]PF6/KOH as the reaction medium. It was found that the in situ-generated carbene fro