68822-97-9

Basic information

• Product Name: 1,8-bis(2-hydroxyphenoxy)-3,6-dioxaoctane
• Synonyms: 1,8-bis(2-hydroxyphenoxy)-3,6-dioxaoctane
• CAS NO: 68822-97-9
• Molecular Weight: 334.369
• Mol File: 68822-97-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,8-bis(2-hydroxyphenoxy)-3,6-dioxaoctane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-bis(2-hydroxyphenoxy)-3,6-dioxaoctane(68822-97-9)
• EPA Substance Registry System: 1,8-bis(2-hydroxyphenoxy)-3,6-dioxaoctane(68822-97-9)

Safety Data

• Hazardous Substances Data: 68822-97-9(Hazardous Substances Data)

Upstream product

• 120-80-9 benzene-1,2-diol 
• 112-26-5 1,2-bis(2-chloroethoxy)ethane 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 112-60-7 Tetraethylene glycol 
• 80322-82-3 triethyleneglycol dimesylate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 6272-38-4 O-benzylcatechol 
• 87117-71-3 2,2'-<1,2-Ethandiylbis(oxy-2,1-ethandiyloxy)>bisphenol-dibenzylether 

Downstream Products

• 106418-55-7 sym-hydroxyphenyldibenzo-19-crown-6 
• 114854-82-9 1,8-bisphenoxy>-3,6-dioxaoctane 
• 87117-70-2 2,2'-<1,2-Ethandiylbis(oxy-2,1-ethandiyloxy)>bisphenol-didodecylether 
• 14098-41-0 dibenzo-21-crown-7 
• 14262-61-4 6,7,9,10,12,13,20,21-octahydrodibenzo[b,h][1,4,7,10,13,16]hexaoxacyclooctadecine 
• 1373139-05-9 C₈₄H₇₆N₈O₁₂S₂Zn 
• 1373139-04-8 C₆₆H₅₆Cl₂N₈O₆S₂Zn 
• 1373139-07-1 C₈₆H₈₀N₈O₁₃S₂Zn 
• 837428-65-6 (1,2-bis[2-(o-hydroxyphenoxy)ethoxy]ethane)thiocyanatoammonium 
• 107573-94-4 24-(4'-methoxyphenylazo)-1,4,7,10,17,26-hexaoxa<10.2.2>orthometaorthobenzenophane 
• 107573-94-4 24-(4'-methoxyphenylazo)-1,4,7,10,17,26-hexaoxa<10.2.2>orthometaorthobenzenophane 
• 193531-56-5 1,8-bis<2-(2-methylsulfonyloxyethyloxy)phenoxy>-3,6-dioxaoctane 
• 193531-54-3 2-{2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-phenoxy}-ethanol 
• 920978-37-6 C₂₈H₃₈O₈ 

Relevant articles and documents

Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous molecular dynamics studies on ligand binding to the β2-adrenergic receptor (β2AR) suggested that ligands pause at transient, less-conserved MBSs. We envisioned that MBSs can be regarded as allosteric binding sites and targeted by homobivalent bitopic ligands linking two identical pharmacophores. Such ligands were designed based on docking of the antagonist (S)-alprenolol into the OBS and an MBS and synthesized. Pharmacological characterization revealed ligands with similar potency and affinity, slightly increased β2/β1AR-selectivity, and/or substantially slower β2AR off-rates compared to (S)-alprenolol. Truncated bitopic ligands suggested the major contribution of the metastable pharmacophore to be a hydrophobic interaction with the β2AR, while the linkers alone decreased the potency of the orthosteric fragment. Altogether, the study underlines the potential of targeting MBSs for improving the pharmacological profiles of ligands.

PHOSPHORUS CONTAINING PODANDS: SYNTHESIS OF DIPHOSPHONIC ACIDS BY THE PHOSPHINYLMETHYLATION OF BISPHENOLS

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Synthesis of Highly Lipophilic Crown Ether Carboxylic Acids

Synthetic routes to eight highly lipophilic crown ether carboxylic acids are described.Structural variations within this series of crown ether carboxylic acids include changes in the crown ether cavity size, the lipophilic group attachment site, and the b