688313-60-2Relevant academic research and scientific papers
Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors
Plewe, Michael B.,Butler, Scott L.,Dress, Klaus R.,Hu, Qiyue,Johnson, Ted W.,Kuehler, Jon E.,Kuki, Atsuo,Lam, Hieu,Liu, Wen,Nowlin, Dawn,Peng, Qinghai,Rahavendran, Sadayappan V.,Tanis, Steven P.,Tran, Khanh T.,Wang, Hai,Yang, Anle,Zhang, Junhu
experimental part, p. 7211 - 7219 (2010/06/13)
HIV-1 integrase (IN) is one of three enzymes encoded by the HIV genome and is essential for viral replication. Recently, HIV-1 IN inhibitors have emerged as a new promising class of therapeutics. Herein, we report the discovery of azaindole carboxylic aci
HIV-INTEGRASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR THEIR USE
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Page 47-48, (2010/02/06)
Bicyclic hydroxamate compounds represented by the Formula I are described. The bicyclic hydroxamate compounds and compositions containing those compounds may be used to inhibit or modulate an enzyme activity of HIV Integrase and to treat HIV mediated dise
