688329-74-0Relevant academic research and scientific papers
Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor α Modulators
Kim, Seongkon,Wu, Jane Y.,Birzin, Elizabeth T.,Frisch, Katalin,Chan, Wanda,Pai, Lee-Yuh,Yang, Yi Tien,Mosley, Ralph T.,Fitzgerald, Paula M. D.,Sharma, Nandini,Dahllund, Johanna,Thorsell, Ann-Gerd,DiNinno, Frank,Rohrer, Susan P.,Schaeffer, James M.,Hammond, Milton L.
, p. 2171 - 2175 (2004)
The discovery and synthesis of dihydrobenzoxathiins as potent, ERα subtype selective ligands are described. The most active analogue, 4-D, was found to be 50-fold selective in a competitive binding assay and 100-fold selective in a transactivation assay i
