688349-25-9

Upstream product

• 129800-98-2 2-(bromomethyl)-3-(phenylsulfonyl)-1-propene 
• 688349-24-8 (4S,5R)-4-Benzyl-5-((E)-3-methoxycarbonyl-allyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 158744-40-2 Ethyl 4(S)-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetate 
• 688810-34-6 (4S,5R)-4-Benzyl-2,2-dimethyl-5-(2-oxo-ethyl)-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 688349-26-0 (4S,5R)-4-Benzyl-5-((1R,5R)-5-methoxycarbonyl-3-methyl-cyclopent-2-enylmethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 688349-27-1 (4S,5R)-4-Benzyl-5-((1R,6R)-6-methoxycarbonyl-4-oxo-cyclohex-2-enylmethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 688349-28-2 (4S,5R)-4-Benzyl-5-((1S,2R)-2-tert-butylcarbamoyl-4-oxo-cyclohexylmethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

HIV protease inhibitors part 2: [3+2] Cycloaddition, isomerization; and ring expansion en route to 4,5-substituted cyclohexenones

4,5-Substituted cyclohexanone 10 and its derivatives are carbocyclic analogues of Indinavir 3 and are expected to have antiviral activity. Early attempts to obtain these compounds via a diastereoselective [3+2] cycloaddition between 19 and 14 failed due t